Postdoctoral Opportunities in Cornea Genetics
Jules Stein Eye Institute, UCLA - Los Angeles, CA

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Postdoctoral positions are available in the Cornea Genetics Laboratory (http://www.jsei.org/aldavelab/) at the Jules Stein Eye Institute on the University of California, Los Angeles campus. The candidates will be highly motivated and have a strong interest in translational research that involves integrating clinical findings with basic research results. The Lab focuses on identifying the genetic basis of the corneal dystrophies by utilizing classical and cutting-edge technologies. The focus of the research currently conducted is on posterior polymorphous corneal dystrophy (PPCD). At least two chromosomal loci have been identified as being involved in the pathogenesis of PPCD: the PPCD1 locus on chromosome 20, in which the genetic basis has not yet been identified; and the PPCD3 locus on chromosome 10, in which truncating mutations in ZEB1 have been identified in approximately 1/3 of affected families. To identify the genetic basis of PPCD1, next-generation resequencing and array-comparative genome hybridization approaches are being employed. Following the identification of the genetic basis of PPCD1, the postdoctoral candidates will be expected to design and perform the relevant functional studies. To elucidate the mechanisms by which ZEB1 mutations result in PPCD, both in vitro (e.g. EMSA) and cell based (primary and immortalized corneal endothelial cells) methods are being utilized.

Candidates are expected to hold a Ph.D and/or M.D. with less than 2 years of postdoctoral experience, be self-motivated and demonstrate a record of research achievement. The first of two postdoctoral positions will require a strong background in cell biology, molecular biology, and genetics. Expertise in cell culture, primary cell isolation, cell transfection, cell-based gene promoter regulation, DNA binding techniques, nucleic acid and protein manipulation, gene expression methodology, and proficiency in microscopy are necessary. The second postdoctoral position will require a strong background in bioinformatics, computational biology, statistical genetics or other relevant areas and proficiency or familiarity with R/Bioconductor, Pearl, C++, and relational databases (MySQL, Microsoft SQL, etc). A working knowledge of high throughput datasets (gene expression array, genotyping, and/or next-generation resequencing) is also preferred.

Interested individuals who meet the above criteria may apply by sending CV to:

Anthony J. Aldave, M.D.
Associate Professor of Ophthalmology
Director, Cornea Genetics Laboratory
Director, Cornea Service
Director, Cornea and Refractive Surgery Fellowship
The Jules Stein Eye Institute
100 Stein Plaza,UCLA
Los Angeles, CA 90095-7003
Fax: 310.794.7906


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