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Vertex Pharmaceuticals

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About Vertex Pharmaceuticals

Vertex Pharmaceuticals aims to cure patients with previously incurable diseases. The biotechnology company uses an integrated, multidisciplinary approach -- employing biophysics, computer-based modeling, and functional genomics -- to speed up the discovery and development of new drugs. Its first commercial product, Incivek (telaprevir) for hepatitis – more... C virus (HCV), was launched in 2011, and a second drug for cystic fibrosis, Kalydeco, was launched in 2012. The company has other drugs in development, including additional treatments for HCV and cystic fibrosis, as well as epilepsy and rheumatoid arthritis.

The company gained FDA approval for its leading hepatitis C candidate telaprevir in mid-2011; the drug was launched as Incivek and represented the first approved drug in a new class of antivirals. The drug is in clinical trials worldwide, and was approved for sale in Canada, Japan, Switzerland, the European Union, and other countries later that year. Vertex has partnered with Johnson & Johnson unit Janssen Pharmaceuticals and Mitsubishi Tanabe Pharma to market the drug in international markets, but has kept North American commercial rights for itself. In anticipation of the drug's FDA approval, in 2010 Vertex set up the sales and marketing infrastructure to support a commercial launch.

Not long after Incivek was launched, the company achieved another success with the FDA approval of cystic fibrosis candidate Kalydeco. Vertex is marketing the drug in the US on its own, and is working to gain approval for the drug in additional countries as well. The Cystic Fibrosis Foundation helped to fund the discovery of Kalydeco (as well as another compound still in development stages), and as a result Vertex pays royalties to the foundation on sales of Kalydeco.

In addition to its additional HCV and cystic fibrosis candidates, other compounds in clinical development are being investigated for the treatment of epilepsy and inflammatory diseases, specifically rheumatoid arthritis, as well as epilepsy and influenza A. Like most discovery and development companies, Vertex depends upon third-party manufacturers to produce the drugs used in its clinical trials. Upon launch of Incivek and Kalydeco, the company maintained the same operating pattern of using third parties to manufacture its products.

Historically, as a development-stage company, Vertex has relied on funding from collaboration and licensing partners to support its research and development efforts, and it continues to seek new partners and acquisition targets to gain new market opportunities. However, achieving commercialization for Incivek in 2011 allowed the firm to grow its revenues exponentially that year (from $143 million to $1.4 billion) and pull its net income level into the black (to some $30 million) for the first time since its founding. As a new therapy in the high-demand HCV marketplace, Incivek achieved some $950 million in sales revenues for the company in the second half of the year alone; in addition Vertex received milestone and royalty payments from both Janssen and Mitsubishi Tanabe upon the commercialization of Incivek in international markets.

Vertex, which was formed in 1989, has research facilities in California, Iowa, and Massachusetts, as well as in Canada and the UK. – less

Vertex Pharmaceuticals Employer Reviews

User Support Analyst (Former Employee), Boston, MAJune 30, 2014
Procurement and Sourcing (Current Employee), Boston, MAJune 17, 2014
Research Support Technician (Former Employee), Cambridge, MAApril 17, 2014
Corporate Services Coordinator (Current Employee), Boston, MAMarch 26, 2014
project manager (Current Employee), Boston, MAFebruary 13, 2014

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Working at Vertex Pharmaceuticals