Associate Scientist/Scientist, Pre-formulation/Formulation
Dart NeuroScience LLC (DNS) is a privately held Delaware Limited Liability Company with offices in San Diego, CA. DNS will discover new technologies and develop new therapies to help maintain cognitive vitality throughout life.
Dart NeuroScience, LLC (DNS) is building a drug product formulation department and is looking for a scientist who has significant experience with pre-formulation, solid state characterization (salts screens & polymorph screens) and physiochemical evaluation of candidate drugs to enable DNS's discovery and development programs. The successful candidate will be actively involved in the characterization of late stage discovery compounds to support medicinal chemistry, DMPK, and pharmacology efforts by identifying compounds with appropriate drug-like properties and providing acceptable formulations for in vivo evaluations of these compounds. Experience with preclinical and early-stage clinical formulations and HPLC method development is highly desirable. The ability to work effectively in a collaborative, interdepartmental team environment is essential to this role with the expectation that this scientist will interact with all disciplines in the drug development pipeline, including discovery, CMC, pre-clinical, clinical and regulatory.
Duties and Responsibilities
Perform physiochemical characterization of drug candidates
Determine optimal polymorph and/or salts of candidate molecules
Evaluate formulations appropriate for animal studies
Perform excipient compatibility studies to enable clinical formulations
Develop phase appropriate analytical methods
Participate in drug discovery team meetings and provide data & guidance to help teams move compounds forward
Work closely with preclinical groups and provide preclinical formulation support (when necessary?)
Work closely with rest of formulation department to move compounds through late discovery into the clinic
A Ph.D. or MS in pharmaceutical sciences, analytical chemistry or chemical engineering with at minimum of 3 years (PhD) or 5 years (MS) of relevant experience in a pharmaceutical/biotechnology company
Demonstrated experience with successfully characterizing small molecule, oral dosage drugs in early stages of development programs; participation in programs that went to the clinic is not required, but would be very helpful
Expertise with instrumentation required for physiochemical and pre-formulation evaluations (e.g. DSC, TGA, DVS, XRPD, HPLC)
CNS drug development experience preferred, but not required
Experience developing HPLC methods is required
Understanding of cGMP requirements desired, but not required
Ability to work with a wide range of disciplines required to get a drug from discovery through clinical development
Excellent verbal, written and interpersonal skills required
Ability to work in a fast-paced organization with diverse project teams and personnel
Expertise demonstrated by published scientific articles in peer-reviewed journals, society participation, regulatory filings and patents
Commitment to excellence
DNS offers competitive salaries and a great benefits package including incentive bonuses, healthcare, vision, dental, long-term disability, life insurance and a 401(k) retirement savings plan.
To apply, please submit your CV or resume using our online application at www.dartneuroscience.com .
Dart NeuroScience LLC - 30+ days ago