BioPhase Solutions specializes in recruiting top talented professionals for San Diego's Scientific community. We are currently looking for a Associate Scientist to work for a leading San Diego biotechnology company.
Experience in protein chemistry (e.g. expression, purification and characterization) is required.
Experience with crystallization, and/or biophysical characterization of proteins would be a decided asset. The candidate must possess good communication skills and work well in a team.
Optimize the expression of constructs and identify clones suitable for enzymatic screening and amenable to X-ray crystallography
Perform both small-scale and large-scale purification of recombinant proteins utilizing standard chromatography techniques with an AKTA FPLC system
Conduct co-crystallization experiments to generate crystals suitable for structure determination of proteins in complex with small molecules to facilitate structure based optimization of lead compounds
Maintain an accurate and detailed laboratory notebook documenting the purification and crystallization experiments, and provide regular reports to the team in large and small group meetings