Position: Development Scientist II, Protein Characterization
Reports to: Director, Protein Characterization
Location: Cheshire, CT
Alexion Pharmaceuticals, Inc. is a biopharmaceutical company focused on serving patients with severe and ultra-rare disorders through the innovation, development and commercialization of life-transforming therapeutic products. Alexion is the global leader in complement inhibition, and has developed and markets Soliris® (eculizumab) as a treatment for patients with PNH and aHUS, two debilitating, ultra-rare and life-threatening disorders caused by chronic uncontrolled complement activation. Soliris is currently approved in more than 35 countries for the treatment of PNH, and in the United States for the treatment of aHUS. Alexion is evaluating other potential indications for Soliris and is pursuing development of other innovative biotechnology product candidates in early stages of development. This press release and further information about Alexion Pharmaceuticals, Inc. can be found at: www.alexionpharma.com.
This position will lead the mass spectrometry part of the protein characterization group. This position reports directly to the Director of Protein Characterization, is expected to work independently, and oversees associates in the lab. The candidate should have an established track record characterizing antibodies, proteins, and peptides. This position will be mostly utilizing mass spectrometry as the major characterization methodology. However, the candidate is expected to be knowledgeable in a broad array of other characterization techniques including chromatography and gel electrophoresis. The candidate should have excellent team, effective organizational, and writing and presentation skills.
1. Experimental characterization and method development for monoclonal antibodies and recombinant proteins by mass spectrometry and other techniques. (50%)
a. Intact molecular weights analysis using LC-ESI-TOF.
b. Peptide mapping using LC-ESI-TOF and ESI-QTOF.
c. Structure and biophysical analysis.
d. Daily operation of MS equipment.
2. Participating in general laboratory operations including equipment maintenance and organization (10%)
3. New technology evaluation (15%)
4. Authoring technical reports, department-specific protocols and general operating procedures (15%) and managing associates (10%)
Alexion Pharmaceuticals, Inc. (Alexion) is a biopharmaceutical company engaged in the discovery, development and delivery of biologic...