Development Scientist II, Protein Characterization
Alexion Pharmaceuticals, Inc. - Cheshire, CT

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Alexion Pharmaceuticals, Inc. is a biopharmaceutical company focused on serving patients with severe and ultra-rare disorders through the innovation, development and commercialization of life-transforming therapeutic products. Alexion is the global leader in complement inhibition, and has developed and markets SolirisĀ® (eculizumab) as a treatment for patients with PNH and aHUS, two debilitating, ultra-rare and life-threatening disorders caused by chronic uncontrolled complement activation. Soliris is currently approved in more than 35 countries for the treatment of PNH, and in the United States for the treatment of aHUS. Alexion is evaluating other potential indications for Soliris and is pursuing development of other innovative biotechnology product candidates in early stages of development. This press release and further information about Alexion Pharmaceuticals, Inc. can be found at: www.alexionpharma.com.

Position Summary:
This position will lead the biophysical characterization part of the protein characterization group. This position reports directly to the Director of Protein Characterization, is expected to work independently, and oversees associates in the lab. The candidate should have an established track record characterizing antibodies, proteins, peptides, and carbohydrates. The candidate is expected to be knowledgeable in all areas of chromatography, peptide sequencing, and binding kinetics and be able to utilize a broad array of other instrumentation. The candidate should have excellent team skills, effective organizational and presentation skills.

Principal Responsibilities:
1. Oversee, method development and preforming biophysical characterization of monoclonal antibodies and recombinant proteins by multiple techniques including: (60%)
  • Surface Plasmon Resonance (Biacore)
  • HPLC carbohydrate analysis
  • N-Terminal sequencing
  • AAA
  • SEC-MALS
  • CD
  • SDS-PAGE
  • IEF
  • 2D-PAGE
  • Enzyme digests
2. New technology evaluation (15%)
3. Authoring technical reports, department-specific protocols and general operating procedures (15%)
4. Managing associates (10%)

About this company
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Alexion Pharmaceuticals, Inc. (Alexion) is a biopharmaceutical company engaged in the discovery, development and delivery of biologic...