Director ADME
Kelly Services - San Diego, CA

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Our client, a leading biotechnology company, is seeking a highly motivated scientist to join our experienced drug discovery and development team. You will make critical contributions to the discovery and development of small molecule drugs that will transform cancer therapy.
The successful candidate will have primary responsibility for and leadership of all ADME research and the ADME team. This will include the planning and performance of a variety of in vitro and in vivo ADME studies e.g. protein binding, enzymatic and cell-based assays to better understand the drug-like or pharmacodynamic properties of our molecules; developing and performing bioanalytical LC/MS/MS methods for pharmacokinetic studies; and clearly communicating and presenting results to others. This role will include hands on work and supervision of more junior ADME scientists.
Requirements: PhD in biochemistry, analytical chemistry, pharmacology or a related field with at least 8-10 years of relevant education and laboratory experience Practical experience i performing in vitro ADME or enzyme assays and cellular assays and ii developing bioanalytical LC/MS/MS methods and applying them to samples from cellular and animal studies A strong working knowledge of the wide range of in vitro ADME assays employed to assess the pharmaceutical properties and potential toxicology or clearance mechanisms of novel compounds
Experience in establishing and maintaining disease models in animals and in extracting interpretable data from experiments designed to assess the effects of drug candidates Experience in screening novel small molecules for exposure in standard PK models in mice, rats and dogs Experience in managing studies and interactions with an external animal facility Flexibility to apply these skills outside of the traditional ADME/PK discipline Excellent written and oral communication skills with an attention to detail Ability to interact with other highly engaged project team scientists and to explain experimental designs, technical constraints, and interpretation of data. Experience organizing and presenting data packages that support the transition of development candidates into early development Well versed in multiple methods of cross species dose predictions using allometric scaling, protein binding, physicochemical properties of the drug or species differences in physiological time, etc.
Desired: Preference will be given to candidates with experience in managing the conduct of testing at CROs, particularly the in-life portion of PK studies Experience in PK and PK/PD analysis and use of relevant software like WinNonlin Current in practice of and regulatory recommendations for evaluation of interactions of drug candidates with small molecule transporters Experience in writing the ADME section of INDs and other clinical reports.

About Kelly Services ®
Kelly Services, Inc. (NASDAQ: KELYA, KELYB) is a leader in providing workforce solutions. Kelly ® offers a comprehensive array of outsourcing and consulting services as well as world-class staffing on a temporary, temporary-to-hire, and direct-hire basis. Serving clients around the globe, Kelly provides employment to more than 560,000 employees annually. Revenue in 2012 was $5.5 billion. Visit kellyservices.com and download The Talent Project , a free iPad ® app by Kelly Services.
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Kelly Services, Inc. (Kelly) is a global temporary staffing provider operating in 36 countries and territories throughout the world. The...