Group Leader, Biological Analysis and Validation
Lead a biological analysis research group as part of an effort to develop novel small molecules for cancer therapeutics. This group will strive to: 1) Validate candidate targets identified from genomic analyses by over-expression and knock-down (RNAi, CRISPR, TALEN, etc.) experiments in cellular systems; 2) Study the biochemical signaling consequences of small molecule inhibitors on sensitive and resistant cells; 3) Generate models with increased resistance and sensitivity to small molecule inhibitors of interest; 4) Design and develop phenotypic screens for cellular lethality, differentiation, apoptosis, in genotypically defined cell populations; 5) Identify biochemical targets for small molecules identified by phenotypic screens. Supervise cellular and biochemical exploration as well as systematic analyses to support these goals. Will work with Senior Group Leader to manage a team of experimental biologists in this effort.
• Supervise a team of experimental biologists in an effort to validate cancer therapeutic targets and perform detailed biological analysis of candidate lead compounds.
• Interact with collaborating teams in other research groups who are leading drug development efforts for particular targets, to facilitate their validation and correlation studies.
• Promote innovative approaches for screening of therapeutic agents, including the design and development of phenotypic screens for cancer cell killing.
• Lead efforts to understand biochemical signaling consequences of target inhibition and for other candidate lead compounds.
• Mentor members of the research team in cell biology, biochemistry, and assay development.
• Communicate with colleagues in Broad’s chemical biology community, the broader academic community and the pharmaceutical research community to facilitate the translation of therapeutic targets into small molecule inhibitor screens.
- PhD in biochemistry, cell biology, molecular biology or related life science.
- 5+ years of post-PhD experience in cancer cell and molecular biology
- Experience in group leadership as well as mentoring.
- Ability to work with a diverse team including computational biologists, chemical biologists and chemists.
- Strong commitment to the goal of developing new cancer therapeutics.
- Excellent oral and written communication skills.
- Computational skills to implement efficient computational strategies on large data sets.