2013 Janssen Pharmaceutical R&D Summer Intern - San Diego Area Job
Johnson & Johnson - San Diego, CA

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2013 Janssen Pharmaceutical R&D Summer Intern - San Diego Area(Job Number: 00000BUF)

Description

Janssen Research & Development, L.L.C, a member of Johnson & Johnson's Family of Companies is recruiting for R&D Summer 2013 Interns. Positions are located in the San Diego, CA area.

Janssen Research & Development, L.L.C. develops treatments that improve the health and lifestyles of people worldwide. Research and development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, infectious disease, diabetes, hematology, metabolic disorders, immunologic disorders, and reproductive medicine.

Janssen Research & Development, L.L.C. offers a variety of Pharmaceutical R&D intern positions in several Pennsylvania, New Jersey or California locations. These individual openings provide students with an opportunity to become an essential part of their respective departments. These assignments offer the students the opportunity to work in either a laboratory or operations setting. This hands-on exposure allows the students to develop and participate in the planning, execution, reporting and data analysis of a wide variety of lab experiments under the guidance from an experienced scientist/engineer or work with cross-functional teams to implement special projects involving capacity or process improvements and cost savings. Interested candidates should have a strong desire to learn the drug development process and contribute to improving the health of people worldwide.

Positions may be available in (but not limited to) the following areas:

Biologics Clinical Pharmacology Sciences: conducts nonclinical and clinical study sample bioanalysis to determine the concentration of Centocor drug products and anti-drug immune response in biological matrices. Scientists, develop and validate new assays and evaluate new technologies for immunoassay development. Once, the assay is transferred to the bioanalytical department, the assays are conducted and reports are written with interpretation of the data. These reports are added to submissions to Health Authority agencies for approval of our products. Centocor is a leader in mAb drug development with successful products and various new therapies in clinical trials. (Locations: PA - Radnor)

Biologics Research: is the starting point and driver for innovative drug development. Scientists, with world-class expertise in a wide variety of subjectsand therapeutic areas, work in a multidisciplinary manner to identify drug targets and pathways that are suspected to play a role in diseases ranging from Cancer to Asthma. Once identified, technology experts apply a particular drug platform to design a compound that modulates the target or pathway in a precise manner. The 'core' technology platform for Centocor is monoclonal antibody (mAb) therapy where the compound is a complex protein derived from the human immune defense system. Centocor is a leader in mAb drug development with successful products and various new therapies in clinical trials. (Locations: PA - Radnor or CA - San Diego)

Biomarkers: is involved in supporting the development and application of biomarkers for Immunology and Oncology drug development programs. The biomarker goals are integrated into the compound development team (CDT) goals and include evaluation of the pharmacologic audit trail to confirm that an experimental agent is interacting with its molecular target in the appropriate disease tissue, that it is having the expected effect on the target and downstream pathway at a safe and tolerable dose. Subsequently, the biomarker team identifies predictive biomarkers for selected programs for use in selecting patients most likely to respond to a targeted therapy. (Location: PA - Radnor)

Drug Safety Sciences: is involved in supporting safety assessments for drug development programs throughout J&J, involving cancer, pain, asthma, and metabolic and CNS diseases. These studies help optimize drug leads and drive them to their first-in-human trials. Scientists contributing to these results are from the departments of Pathology, Genetic Toxicology, and Investigative Toxicology and Safety Biomarkers. Many different analytical technologies, some proven and traditional, others cutting-edge, are used to ascertain the effects of a drug and provide valuable information about possible adverse events. This information is a required part of the final submission to regulatory agencies such as the FDA. (Location: NJ - Raritan)

Drug Metabolism and Pharmacokinetics (DMPK): a part of Drug Safety Sciences conducts research into identification and quantitation of endogenous biomarkers of cytochrome P450 3A4, as well as other P450 isoforms as surrogate markers of drug-drug interactions in humans. Additional areas of research include metabolism of therapeutic peptides and proteins, and covalent modification of proteins. (Location: NJ - Raritan)

Drug Transporters: the Drug Metabolism and Pharmacokinetics (DMPK) department of Drug Safety Sciences is involved in examining transport of compounds using various mammalian expression systems and other cutting edge methodologies. These data are used to mechanistically understand the disposition of compounds and assess potential for drug-drug interactions and/or issues related to the disposition of compounds in man. (Location: NJ - Raritan)

Immunology Discovery: is a function dedicated to the identification of new targets that play a role in immune mediated disease e.g. Rheumatoid Arthritis. Once identified, the Discovery teams use in vitro cell-based and in vivo pharmacology systems to validate the targets role in certain disease pathways and, when ready, partner with small and large molecule drug platform teams to develop high quality therapeutics that modulate the target and pathway. Once developed, Discovery scientists support the pre-clinical and clinical development paths leading to the eventual launch of the product e.g. Stelara®, a monoclonal antibody that inhibits IL-12/23 and is used for the treatment of Psoriasis. (Locations: PA-Radnor, CA-La Jolla)

Pharmaceutical Development and Manufacturing Sciences (PDMS): is the organization that takes the new molecules identified by the Discovery group, and turns them into a reality....we transform molecules into medicine! We work cross functionally to develop the technology used in the large-scale manufacture of pharmaceutical products. We develop the processes for bulk and drug product formulation along with the analytical methods used to assure the quality of our processes and product. We have groups developing the devices used to deliver the drug formulations safely and effectively and the packages used to assure the integrity of product delivered to our patients. The group is also responsible for the manufacture of toxicology supplies and clinical supplies in our Pilot Plant facilities. However, our work does not stop with the commercialization of the process. PDMS is also responsible for ongoing technical support of our commercialized products throughout their life cycle. (Locations: PA - Radnor, Malvern, Springhouse or NJ - Raritan)

Neuroscience: discovers medicines to treat neuropsychiatric diseases - especially disorders of mood and cognition. Our discovery strategy focuses in part on the use of highly translatable preclinical models. To enhance this key effort, we now seek a highly motivated candidate to participate in behavioral work related to mood and cognition. The candidate will work on established models, help set up novel models, and combine behavior with molecular and cellular biology techniques, in order to develop novel approaches for CNS therapeutics. The candidate will be an active participant in a research environment working with a team of experienced behavioral pharmacologists. (Locations: CA- La Jolla)

Qualifications

Candidates must be working towards a B.S., M.S., or PhD degree in Chemistry, Analytical Chemistry, Chemical Engineering, Biochemistry, Biology, Molecular Biology, Microbiology, Biotechnology, Biochemical, Biomedical Engineering, Neuroscience, Pharmaceutical Sciences, or other science/lifescience related concentration. The successful candidate will be familiar with a basic scientific techniques and experience working in a laboratory environment. It is essential that candidate be self-motivated, productive and have excellent computer and scientific problem solving skills. Extensive PC based skills, including Microsoft Excel, Word, Project and PowerPoint is preferred. Qualified candidates must have the ability to work independently and as part of a team and have strong interpersonal, analytical, and leadership skills. Good verbal and written communication skills are required.

Students must be able to provide their own transportation to/from their work location. Students must be legally authorized to work in the United States and not require future sponsorship for employment visa status (e.g. H1-B status) now or in the future.

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Primary Location: North America-United States-California-San Diego
Other Locations: North America-United States-California-La Jolla
Organization: Janssen Research & Development, LLC. (6084)

Job : R&D

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