The mission of the Palo Alto Institute for Research and Education, Inc. (PAIRE) is to facilitate research and education activities conducted at the VA Palo Alto Health Care System (VAPAHCS). The range of research activities is broad and includes special emphasis on biomedical, health services, rehabilitation engineering, mental health and geriatric research endeavors. We also support various educational instruction or other learning experiences of benefit to employees and veterans.
PAIRE is a nonprofit foundation affiliated with the Veterans Affairs Palo Alto Health Care System (VAPAHCS). A postdoctoral position is available immediately in the laboratory of Lawrence Leung M.D., and John Morser Ph.D., in Hematology at the Stanford University School of Medicine and Principal Investigators in the VA Palo Alto Health Care System.
The laboratory is currently involved in a NIH-funded effort investigating the physiological or pathological role(s) of proteolytic cleavage of chemerin and osteopontin by enzymes in the clotting system.
Our long-term interest is to have a better understanding of the interactions between thrombosis, inflammation, and innate immunity. We have focused on thrombin, the key effector enzyme in the blood clotting cascade. Using a library of thrombin mutants generated by site-directed mutagenesis, we have mapped the critical functional sites on thrombin for its interactions with its diverse substrates. We are studying three key substrates including: 1) thrombin-activatable carboxypeptidase (CPB2) that plays a key role in the physiologic regulation of thrombin’s pro-thrombotic and pro-inflammatory properties, 2) an extra-cellular matrix protein that can also function as a chemoattractant, osteopontin, and 3) a novel adipokine, chemerin.
We are looking for highly motivated postdoctoral candidates with a PhD in molecular or cell biology, biochemistry, or related discipline, with deep knowledge of protein chemistry. The successful candidate should have a good publication record, be experienced in cell culture and protein characterization, familiar with scientific computing, and have good scientific writing skills. Experience in enzyme kinetics and mouse models are highly desirable.
The Division of Hematology at the Stanford University School of Medicine provides training opportunities at the postdoctoral level in the very latest and most sophisticated methods and approaches for investigating the interactions between coagulation, fibrinolysis and inflammation.
This is a full-time, regular, exempt position.
- Study of the cleavages of chemerin and properties of the resultant cleaved chemerins ;
- Investigate the consequences of osteopontin cleavage on cell properties ;
- Collaborate with other members of lab on testing effects of osteopontin and chemerin on dendritic cells ;
- Preparing papers/manuscripts for presentations/publications .
Environmental Conditions / Physical Demands:
- Ph.D. or equivalent in Biochemistry, Protein Chemistry, Cell Biology or Molecular Biology;
- Proficiency in general molecular biology techniques, such as expression and purification of recombinant proteins ;
- Proficiency in protein biochemistry with experience with protein purification and characterization. Experience in enzymology will be a strong plus ;
- Fluency in English and strong communications skills are needed ;
- Working knowledge of standard laboratory computing ;
- Ability to analyze data and familiarity with statistics;
- Proven knowledge in field of research study/program;
- Experienced in a variety of research techniques/methods and follow-up data collection;
- Attention to detail and good organizational skills;
- Ability to use library resources to keep up to date on theoretical/scientific aspects of study/program .
All PAIRE positions require the completion of a background check.
- Regular exposure to a lab environment
- Potential exposure to blood borne pathogens
- Exposure to toxic or caustic chemicals or reagents
PAIRE is pleased to be an Equal Opportunity Employer. If you are interested in applying for employment with PAIRE and need special assistance or an accommodation to apply for a posted position, contact our Human Resources department at firstname.lastname@example.org .