PhD or MD
***This position is contingent upon external funds***
A postdoctoral fellowship is available at The Children’s Hospital Oakland Research Institute (CHORI, www.CHORI.org ), a biomedical research institute located in the San Francisco Bay Area. With world-class scientists and research centers known nationally and internationally in multiple fields, CHORI is highly ranked among pediatric medical centers for NIH funding.This position is in both the Center for Genetics and the Center for the Prevention of Obesity, Cardiovascular Disease & Diabetes. The purpose of the position is to support a cutting-edge pharmacogenomics research project focused on investigating the genetic and molecular determinants that contribute to human variation in statin drug response. The results of this research could yield significant improvement in the ability to identify those individuals most likely to achieve cardiovascular benefit from statin treatment, as well as investigate the potential future use of statins in the treatment of cancer.
The fellowship position is within the laboratory of Dr. Marisa Medina and involves two major project areas:
1) The investigation of novel mechanisms of RNA regulation responsible for the maintenance of intracellular cholesterol homeostasis and sterol metabolism under both normal physiological conditions and in response to cholesterol lowering drugs using molecular techniques, in vitro model systems and potentially animal models.
2) Identification of human gene variants that impact RNA regulation and thus underlie inter-individual variation in plasma cholesterol and response to cholesterol lowering drugs.
This is a superb opportunity for collaborative work both within the Center for the Prevention of Cardiovascular Disease, Obesity and Diabetes at CHORI, as well as with our extensive network of external collaborators representing a wide range of scientific disciplines.
An PhD or MD/PhD is required. The applicant should have a background in genetics and lipid metabolism, as well as substantial experience in a diversity of molecular biology techniques. Previous experience with RNAseq, microRNA, and cell culture is particularly desired. Applicants should have excellent organization and communication skills, and will be expected to critically analyze and report research findings in major journals and national meetings. Initiative and scientific engagement are exceedingly valued within this particular laboratory workplace community. The position allows for attendance at the CHORI Faculty Seminar Series, Children’s Hospital Oakland Grand Rounds, monthly seminars given by visiting scientists, and on-site journal clubs in a variety of disciplines. The employee with exceptional leadership abilities and work ethic will also have the opportunity to present their project progress to the CHORI scientific community via slide presentation and/or poster session. For the highest caliber employee, mentorship and opportunities to contribute to projects leading to abstract submission at national scientific conferences and journal publication are available. The position affords numerous additional opportunities for career growth, workplace education, and advancement.
Postdoctoral Position Summary:
Conducts laboratory and/or clinical research under the close supervision of a Principal Investigator. Postdoctoral Fellows are generally appointed for a limited term, usually one to three years. In certain circumstances, a Postdoctoral Fellow may be promoted to the rank of Senior Postdoctoral Fellow. The total time spent in the ranks of Postdoctoral Fellow and Senior Postdoctoral Fellow will not exceed six years.
Background & Accomplishments:
Has an outstanding understanding of scientific background in one or more research areas. Has ability to understand, adapt, and with guidance, set up experimental protocols and analytical procedures. Possesses scientific writing skills as evidenced by peer-review publication record.
Interpersonal SKills & Management SKills/Goals:
Promotes a constructive and positive atmosphere within the work area by cooperating with and assisting investigators and other staff. Is an effective problem solver through active problem identification and collaboration with investigators and other staff. Interacts with others in a courteous, professional manner with appropriate confidentiality. Uses appropriate organizational skills in setting priorities for work and meeting deadlines. Is able to resolve conflicts in a pro-active manner that demonstrates a high level of understanding of and interest in conflict resolution. Contributes to Institutional affairs as appropriate.
Postdoctoral Fellow with 0-3 years experience; Ph.D. or MD. Learns new and/or advanced research skills and techniques. Participates in design of experiments and interpretation of results. Originates publication and presentation of data from laboratory. May seek and obtain external grant funding
Senior Postdoctoral Fellow with 3+ years experience; Ph.D. or MD. In addition to Postdoctoral Fellow responsibilities, may supervise staff membe(s). May obtain grant or fellowship funding. Shows potential for independent research through continued publications and presentations
Sit: Up to 8 hours/day
Stand/Walk: Up to 6 hours/day
Bend/Stoop: Up to 6 hours/day
Reach: Up to 6 hours
Rep Use of UE/Grasp: Up to 8 hrs
Lift/Push/Pull: 25lbs, over 25# with assistance or equipment
This job requires the ability to hear alarms clients and/or instruction. The ability to see accurately from 20 inches to 20-ft. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential function of this position.