Principal/Senior Scientist, Physiology
BioPhase Solutions - San Diego, CA

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BioPhase Solutions specializes in recruiting top talented professionals for San Diego's Scientific community. We are currently looking for a Principal/Senior Scientist, Physiology to work for a leading San Diego biotechnology company.

Principal/Senior Scientist, Physiology

We seek an exceptional Scientist with immunology expertise to join the physiology team in the development of therapeutics from Physiocrines. The successful candidate will play an instrumental role in the exploration of these novel Phyisocrine proteins in animal models and in ex vivo culture systems. These data will form the basis of transformative medicines for patients with significant unmet needs.

Specifically, the scientist will conduct, analyze, interpret and report pre-clinical proof-of-concept studies and in collaboration with outside vendors. The successful candidate will be responsible for feasibility assessments of various formulations and dosing strategies in pre-clinical studies and the impact of these parameters on potential biomarkers of efficacy for translation to clinical trials. The candidate will also assist in the identification of new clinical indications for Physciocrine proteins.


The successful candidate must be experienced with state-of-the art animal models and IND enabling pre-clinical studies. A deep understanding of immune-mediated disease mechanisms is critical. Experience in the assessment of the impact of drug candidates on the clinical and histologic aspects of muscle disease and a track record in a successful biological license application will be considered very favorably.

Must be a decisive, independent thinker and excellent mentor and teacher. The candidate will be an excellent written and verbal communicator, and will lead by example. In this role, the scientist will interact effectively with the Physiology, company leaders, and collaborators at academic institutions and CROs. In addition, the successful candidate will have demonstrated statistical and analytical skills and an excellent publication record in high-level peer reviewed journals.

The candidate will also have the capacity to:
Create and implement innovative and efficient operational processes

Author pre-clinical sections of regulatory documents

Present progress, data, interpretations and next steps to management and corporate partners

Work well in dynamic high-paced team environment

Maintain deep and current understanding of relevant biomedical literature

Must have a Ph.D. from a leading university and at least 8 years of experience in the pharmaceutical or biotechnology industry, ideally in biologics and pharmacology.

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