Working under moderate supervision, perform research work in medial and related technical areas involving the use of lab/ research skills. The research focuses on the understanding of the mechanism of oligodendrocyte development, myelin formation, myelin repair, and its related disease conditions, such as multiple sclerosis. The research assistant is expected to handle rodent animals (mouse and rats), perfuse and analyze tissue samples using basic histologic techniques, biochemical analysis such as Western blot and perform small animal surgery. The individual will be expected to do mouse genotyping and maintain colonies of rodents in the Animal Resource Center (ARC) facility and maintain compliance to ARC policies and all applicable regulations for animal research and care.
Maintain rodent (knockout and transgenic mouse) colonies in the animal facility, including cataloging, breeding and genotyping.
Perform animal perfusion with dissection and embedding of tissues.
Perform cryostat and vibratome sectioning and staining.
Analyze samples using histology, immunohistochemistry, and Western blot.
Record results, maintain accurate and detailed records of research data, and update electronic databases as needed.
Order laboratory supplies
Maintain test equipment utilized in experiments.
Perform other duties as assigned.
Department: Frequent contact with the principal investigators, postdocs, and staff for instruction and discussion of data, as well as contacting lab members regarding animal and issues that may arise in the animal resource center (ARC). There will be occasional contact with other labs within the department regarding experimental collaborations and departmental administrative staff for assistance with laboratory orders.
University: Regular contact with ARC and Institutional Animal Care and Use Committee (IACUC) staff regarding animal issues and compliance. Occasional contact with staff members of the department of Occupational and Environmental Safety (DOES) regarding chemical safety compliance.
External: Infrequent contact with laboratories around the U.S. regarding animal transfers.
Students: Occasional contact with students for training and assistance in technological aspects of their research projects.
No supervisory responsibility.
Education/Experience: Bachelor's degree and 0 to 1 year of experience or Associate's degree in an approved biotechnology program and 0 to 2 years of experience.
Understanding of neuroscience, developmental biology, biochemistry or molecular biology preferred.
Experience in rodent animal handling.
Basic knowledge of histological techniques.
Basic math and chemistry skills
Professional and effective verbal and written communication skills and strong interpersonal skills; must demonstrate the ability to work and communicate effectively with individuals within and external to the university and in a team environment.
Must demonstrate compliance with ARC policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines.
Must demonstrate compassion for animals within the ARC facilities and dedication to ARC’s mission.Must handle animals with care and respect at all times.
Excellent computer skills, proficiency in Microsoft Office and Photoshop; familiarity with MS Office applications, database programs, and Internet navigation.
Good organizational skills; ability to multitask; and give attention to detail.
Ability to learn and operate laboratory equipment to perform required experiments
Must demonstrate willingness to learn new techniques, procedures, processes, and computer programs as needed.
Work will be performed in a laboratory and employee will be exposed to animals and chemicals.
Case's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals” appropriate Federal Animal Welfare Regulations, and the Public Health Service “Policy on the Humane Care and Use of Laboratory Animals."This position, and all animal research personnel, are subject to internal compliance to ARC SOP’s and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.