Research Associate to Scientist, Molecular Engineering
Astellas Pharmaceuticals 3.748 reviews - Santa Monica, CA

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At Agensys, we're changing tomorrow by moving oncology forward. We've developed a pipeline of novel therapeutic fully human monoclonal antibodies (MAbs) to treat solid tumors based on our own proprietary targets. We have discovered and validated a portfolio of clinically relevant targets in 14 different cancer types. Our pipeline includes therapeutic MAbs to multiple cancer indications that are at different stages of clinical and pre-clinical development.

Our parent company, Astellas Pharma US helps us shine. Together we are the bright spot in the pharmaceutical industry -- not just because of what we do, but in the way we do it. If you are looking for a company where you can change a life, make a dream come true, and light the way for a better tomorrow, this is the place for you.

Astellas, and our Agensys subsidiary, offer a different kind of work culture. A high standard of ethics is mandatory. Quality is our pledge. Diversity is valued. Individual initiative is rewarded. Astellas offers an environment where our employees can make a real difference. To continue to change tomorrow, Astellas/Agensys must recruit the best and brightest in the industry.

Come, shine with us.

Purpose & Scope of Position: The Applied Molecular Biology Department is seeking a highly motivated scientist to support antibody engineering efforts.

Essential responsibilities include but are not limited to:
- Antibody sequencing and comparative analysis of rearrangement and somatic hypermutations
- Design and execution of structure-based antibody engineering for improved antibody properties
- Hands-on application of antibody engineering using in vitro phage display system
- Work both independently and in collaboration with therapeutic functional area to advance Agensys programs
- Present scientific research findings to cross-functional teams

Required Qualifications:

The successful candidate will have a degree in molecular biology, antibody/protein engineering, or related field with 5+ years of experience, preferably in industry. The position requires scientific and technical proficiency in molecular cloning, expression vector engineering, as well as knowledge in antibody structure and function, familiarity with antibody engineering methods applications, and hands-on experience in antibody phage display. The ideal candidate must be proficient in protein randomization methods and large randomized library generation. Experience with automation and high throughput screening is a plus.

The candidate must be highly motivated, have excellent organizational and communication skills, and be able to work independently and as part of a multi-disciplinary team.


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