Research Scientist
Broad Institute 17 reviews - Cambridge, MA

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The Broad Institute is in search of a highly motivated and capable Research Scientist to join the Therapeutics Projects Group (TPG). TPG is committed to developing and applying novel drug discovery approaches and technologies to address critical unmet medical needs not being tackled elsewhere. The successful candidate will share this commitment and be part of a multidisciplinary team that drives innovation to solve therapeutic challenges. The primary role involves structural biology: establishing and utilizing protein crystallography capabilities to advance therapeutic programs through structural insights. More specifically, responsibilities include:
• Establishing a robust, state-of-the-art crystallographic laboratory
• Integrating structural biology expertise into cross-functional project teams
• Leading the determination of high quality protein structures and co-crystal structures through crystallization, data collection and refinement
• Supporting the crystallographic pipeline through protein design, expression and purification
• Communicating effectively with medicinal and computational chemists to advance therapeutic programs
• Exhibiting independent scientific troubleshooting, time management and laboratory operation abilities
• Investigating and implementing new technologies based on scientific needs
• Training others in areas of expertise
Requirements:
Ph.D in Structural Biology or a related field with at least 2 years of post-degree research experience in an industrial or academic setting
• Expertise in protein crystallization, in-house and synchrotron-based data collection
• Expertise in computational crystallographic data processing, experimental phasing and model refinement
• Significant experience in recombinant protein expression and purification
• Experience with high-throughput crystallization and imaging technologies
• A proven record of successful interaction with project team members, external customers or vendors
• Experience with structure-based ligand refinement and fragment-based lead generation approaches preferred
The successful candidate will be a results-focused, team-oriented, creative bench and computational scientist able to excel in a fast-track environment. She or he must be self-motivated, detail-oriented and exhibit strong problem solving skills. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with project teams, peers, and management in identifying and achieving research goals.

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