Scientist, Computational Chemistry Dart NeuroScience LLC -
San Diego, CA
Scientist, Scientific Computing, Computational Chemistry
Dart NeuroScience LLC (DNS) is a privately held Delaware Limited Liability Company with offices in San Diego CA. DNS will discover new technologies and develop new therapies to help maintain cognitive vitality throughout life. DNS’s Scientific Computing Department focuses on (i) development of novel bioinformatic tools to facilitate gene discovery, (ii) development of novel software tools to facilitate drug discovery, (iii) computational chemistry project support, structure-based drug design, combinatorial chemistry and statistical modeling, (iii) information systems and automation and (iv) general IT infrastructure to support scientific research and company administration.
The successful candidate will have broad knowledge and experience applying computational chemistry to solve complex scientific problems in the pharmaceutical industry. S/he will support small-molecule design teams from early screening through lead optimization using computational chemistry. A solid understanding of structure-based and ligand-based drug design is required. The successful candidate will be expected to make individual contributions to drug discovery projects and enhance the composition of the DNS compound collection through computer-aided design. As a senior scientist, the successful candidate will be expected to independently design and execute computational experiments to contribute to the discovery and/or optimization of lead chemical matter. The candidate will have strong theory and chemistry foundations and be able to work with the Methods (software), Information Management and Bioinformatics groups within the Scientific Computing Department to develop novel computational tools to facilitate small-molecule design. The position requires the candidate to recognize how computational chemistry can positively affect the drug discovery process and apply the appropriate methods at the appropriate stages.
Requirements :
Ph.D. with 8+ years experience (or M.S with 15+) in computer-aided design in the pharmaceutical industry. CNS experience is preferred.
Extensive experience with structure-based methods such as docking, molecular mechanics and homology modeling AND/OR ligand-based methods such as pharmacophores and QSAR are preferred. Knowledge of statistical modeling methods and experience using the ChemAxon and OpenEye chemistry toolkits and Schrödinger Software would be a plus.
A strong background in chemistry and computational design.
A strong understanding of good medicinal chemistry drug design principles, including the relationships between chemical properties and the permeability and metabolism of compounds.
Strong leadership skills with the ability to manage the computational tasks on multiple discovery projects.
Good oral and written communication skills and the ability to communicate with medicinal chemistry, informatics, bioinformatics and software developers are a must.
DNS offers competitive salaries and a great benefits package including incentive bonuses, healthcare, vision, dental, long-term disability, life insurance, flexible spending and a 401(k) retirement savings plan.
Interested individuals should submit a cover letter, resume, and list of publications using our online application. PDF files are strongly encouraged.
For more information please visit our web site at www.dartneuroscience.com.
Dart NeuroScience LLC - 10 months ago
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