Scientist, Drug Evaluation
Otsuka - Rockville, MD

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The Scientist, Drug Evaluation, will: • initiate, direct, and execute all OMML pre-clinical scientific research and/or development strategies in an oncology field• investigate the feasibility of applying a wide variety of scientific principles and concepts to potential inventions, products and problems• plan and execute laboratory research• maintain knowledge of state-of-the-art principles and theories• make major contributions to scientific literature and conferences• interface with various departments and serve as internal consultant• act as spokesperson on corporate research and development and advise top management• participate in development of patent applicationsWhen involved in an anti-cancer drug discovery project, the Scientist, Drug Evaluation will: • conduct target validation study using genetically modified animals, and efficacy study of hit compounds in xenograft animal models, including PK analysis• contribute to a study design process by data from pilot study• contribute to a lead-optimization process in collaboration with a medicinal chemistry group, based in Japan• develop multiple animal models, including orthotropic tumor model, to evaluate anti-cancer effect of compounds or biologics• execute in-vivo experiments to characterize and validate novel targets• collect and interpret data in terms of correlation between in vitro and in vivo activity• provide medicinal chemists with wet data for structure-activity relationship analysis• prepare technical reports, summaries, protocols and quantitative analyses• maintain broad knowledge of state-of-the-art principles and theories• oversee in vivo experiment operations, including scheduling, drug administration and data flow• modify and optimize animal models for lead validation and optimization• isolate cells, DNA, RNA and protein from tumors, analyze the samples by immunohistochemistry, flow cytometry, Real-Time PCR and immunoblotting• use gene knockout or knockdown technologies, including siRNA, shRNA and Zinc Finger nuclease for target validation in vitro and in vivo• work with manufacturing and quality control to develop tests, as well as analyze and report results

American Association of Pharmaceutical Scientists - 2 years ago - save job
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Otsuka America is the holding company for the US operations of Japan's  Otsuka Pharmaceutical. Otsuka America oversees pharmaceutical...