Scientist, Oncology Biomarker Development
Genentech, Inc. - San Francisco, CA

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Date: Nov 25, 2013

Job Function: Development

Company/Division: Pharmaceuticals

Schedule : Full-time

Job type:

Job Level: Experienced

Who We Are At the Roche Group, about 80,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 30 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. The headquarters for Roche pharmaceutical operations in the United States, Genentech has multiple therapies on the market for cancer and other serious illnesses. Please take this opportunity to learn about Genentech, where we believe that our employees are our most important asset and are dedicated to remaining a great place to work.

The Position We seek a highly motivated and capable scientist to support biomarker development efforts for Genentech's hematology pipeline. Specifically, this individual will support biomarker activities on GDC -0199, a Bcl-2 inhibitor that is in late stage development for hematological malignancies.

Key responsibilities for this position
Responsibilities will include development of the biomarker strategy to support the clinical development of the Bcl-2 inhibitor for specific heme indications. Scope of biomarker activities will span predictive, pharmacodynamic, and prognostic biomarkers as well as surrogate response markers such as MRD (minimal residual disease). He/she will lead a small laboratory focused on molecule program support. The Biomarker Scientist will be responsible for translating the preclinical hypothesis into a clinical biomarker strategy, incorporating biomarker assays into clinical studies, as well as support companion diagnostic development. In addition, he/she will lead and/or provide support to the Department lead on the biomarker subteam, as well as serve as a biomarker representative on the molecule's Development team or on disease strategy teams.

Who You Are The ideal candidate will have a strong understanding of disease biology, prognostic markers, and oncogenic drivers in one or more of the following: acute myeloid leukemia ( AML ), multiple myeloma (MM), or B-cell malignancies ( CLL , DLBCL , follicular lymphoma). Success in this role will require the candidate to develop a deep understanding of disease biology and heterogeneity, as well as Bcl-2 pathway biology to distill down key biomarker assays that will help understand the drivers of drug response in early phase clinical trials and then to drive companion diagnostic development to support patient selection in late stage trials. Examples of biomarker assays include Bcl-2 immunohistochemistry, targeted next-gen sequencing leukemia panel, predictive and prognostic gene expression signatures using Fluidigm or Nanostring. The Biomarker Scientist will also seek out external collaborations with disease area experts to build a biomarker database using clinically annotated samples.

A strong background in hematology and/or apoptosis signaling evidenced by peer-reviewed publications in top journals, would be an important asset. Candidate would need a PhD degree in a relevant scientific field (e.g. cancer biology, molecular oncology, immunology, pathology). Additional requirement would be a minimum of 5-10 years post-doctoral experience in basic or translational research either in an academic and/or industry setting, desirably in a leading hematology lab.

Key qualities in the candidate are strong scientific skills and also strong communication skills to effectively function in a fast-paced team for a late stage development molecule. We are looking for an individual who would be passionate about using our understanding of disease biology to make impactful contributions to clinical drug development.

General expectations for a Scientist in Oncology Biomarker Development ( OBD ):
The successful candidate is expected to have their own laboratory, lead cross-functional teams, publish innovative biomarker or disease focused research in high quality scientific or medical journals. Additionally he/she will present to our key investigators at meetings and promote collaborative efforts to push biomarker sciences forward. Scientists are expected to be, or develop into, externally recognized leaders in clinical translational sciences.
  • Provide exceptional scientific leadership within OBD , as well as to other functions, subteams / teams at Genentech / Roche.
  • Drive scientific and technical innovation collaboratively with other members of the Department Lead on one or more biomarker subteams
  • Develop and execute on lead and exploratory biomarker strategies for one or more projects
  • Participate in, or lead, disease focused translational biomarker programs, or develop a key focus on novel technologies that advance clinical biomarker assessment
  • Publish in high quality scientific, technical or medical journals
  • Represent OBD externally through presentations at key National / International meetings, interactions with our key investigators
  • Participate and thrive in an interactive, team oriented culture
  • Experience in clinical drug development and biomarkers is beneficial.
  • Consistent record of cutting edge research and / or clinically-related science as evidenced by first- or senior-authored publications in top-tier journals
  • Recognized scientific leadership as documented by references and external presentations
  • Outstanding presentation and communication skills
  • Ability to lead, influence and motivate others
  • Able to distill complex issues and clearly articulate solutions
  • Ability to demonstrate effectiveness and growth in a fast-paced and
Genentech is an Equal Opportunity Employer.

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Genentech, Inc. (Genentech) is a biotechnology company that discovers, develops, manufactures and commercializes pharmaceutical products to...