Scientist (ADC Catabolite ID), Drug Metabolism and Pharmacokinetics (DMPK)
Genentech, Inc. - San Francisco, CA

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Date: Nov 25, 2013

Job Function: Research

Company/Division: Pharmaceuticals

Schedule: Full-time

Job type:

Job Level: Experienced

Who We Are At the Roche Group, about 80,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 30 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. The headquarters for Roche pharmaceutical operations in the United States, Genentech has multiple therapies on the market for cancer and other serious illnesses. Please take this opportunity to learn about Genentech, where we believe that our employees are our most important asset and are dedicated to remaining a great place to work.

The Position Drug Metabolism and Pharmacokinetics ( DMPK )
The DMPK group is dedicated to enabling the discovery, development and commercialization of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion and pharmacokinetic properties of small molecule drug candidates and ADC . We accomplish this through the application of state of the art technologies and sciences of bioanalysis, drug metabolism, drug transport and pharmacokinetics. The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

The department of Drug Metabolism and Pharmacokinetics ( DMPK ) at Genentech is seeking a highly motivated candidate with experience in supporting antibody drug conjugate ( ADC ) projects in discovery and development. The candidate will work on identifying catabolites from various in vitro or in vivo sources. He/she will work to develop and implement various in vitro assays that could be used to better predict in vivo disposition of ADC . The candidate will participate in planning, performing and interpreting results. He/she will work closely with project teams to guide the teams in drug design with respect to improving the next generation of ADC molecules.

This position requires an excellent understanding of metabolism sciences especially on hydrolases, in vitro systems (subcellular fractions, cells and tissues), and bioanalytical techniques, plus knowledge of ADCs and/or antibodies

Who You Are A Ph.D. degree is desirable in pharmaceutical, biological, chemical or any other relevant programs with a strong experimental metabolism background with at least 5 years of relevant industrial/post-doc experience. Hands-on experience with chromatographic separation by LC and small molecules structural elucidation by MS/MS analysis (knowledge of large molecule bioanalysis – in particular ADCs – is a plus). Experience with in vitro ADME studies and capable of trouble-shooting assays. Must be highly motivated, organized, excellent communication skills (both oral and written), detail oriented, and a good team player. A good understanding of clearance mechanisms of both small and large molecule is a plus.

Genentech is an Equal Opportunity Employer.

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Genentech, Inc. (Genentech) is a biotechnology company that discovers, develops, manufactures and commercializes pharmaceutical products to...