Scientist III (CA)
ClinForce, LLC - Emeryville, CA

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the successful candidate will design, execute and interpret in vitro and in vivo metabolism studies to understand the routes of biotransformation and mechanisms of elimination of small molecules. This person will utilize state-of-the-art high resolution LC/MS/MS systems with novel data acquisition and interpretation software to carry out rapid “soft spot” analysis of drug candidates in a fast-paced discovery environment. In addition, in silico metabolite prediction software will be utilized to accelerate the speed and efficiency of data interpretation. Simultaneous quantitative analysis/metabolite identification experiments will be performed for in vitro metabolic stability and in vivo PK and PK/PD studies.A solid understanding of the biochemistry of drug metabolism reactions including redox reactions, hydrolyses, and conjugations.
Experience utilizing advanced LC/MS/MS techniques including accurate mass, mass defect filtering, and simultaneous quantitative analysis/metabolite identification.
Experience in interpretation of CID spectra and fragmentation mechanisms

Climber.com Catalyst - 19 months ago - save job - block
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