Position Type :
Experience Level :
Start Date / End Date :
02/18/2013 / 05/18/2013
Job Title: Scientist III
Job Category: Clinical and Scientific
Investigator, Metabolism and Pharmacokinetics
MAP (Metabolism and Pharmacokinetics) department is responsible for supporting drug discovery efforts by swiftly delivering a thorough understanding of the pharmacokinetics and metabolic fate of novel chemical entities, rapidly characterizing the ADME properties of medicinal chemistry compounds, and assessing PK/PD relationships of drug discovery candidates. The department supports all aspects of metabolism and pharmacokinetics via in vitro, in silico, ex vivo and in vivo studies to ensure delivery of compounds with good drug-like properties for pre-clinical development.
About the position:
The Metabolism and Pharmacokinetics (MAP) department in Emeryville is seeking a highly motivated and team oriented individual to support metabolism and biotransformation studies. Working closely with drug discovery project teams, the successful candidate will design, execute and interpret in vitro and in vivo metabolism studies to understand the routes of biotransformation and mechanisms of elimination of small molecules. This person will utilize state-of-the-art high resolution LC/MS/MS systems with novel data acquisition and interpretation software to carry out rapid “soft spot” analysis of drug candidates in a fast-paced discovery environment. In addition, in silico metabolite prediction software will be utilized to accelerate the speed and efficiency of data interpretation. Simultaneous quantitative analysis/metabolite identification experiments will be performed for in vitro metabolic stability and in vivo PK and PK/PD studies.
A solid understanding of the biochemistry of drug metabolism reactions including redox reactions, hydrolyses, and conjugations.
Experience utilizing advanced LC/MS/MS techniques including accurate mass, mass defect filtering, and simultaneous quantitative analysis/metabolite identification.
Experience in interpretation of CID spectra and fragmentation mechanisms.
Demonstrated experience supporting lead optimization programs and working closely with discovery project teams.
Hands-on experience performing in vitro metabolism experiments such as liver microsome and hepatocyte incubations is required.
A thorough understanding of the underlying principles of drug metabolism, pharmacokinetics and analytical chemistry is essential.
Strong written and verbal communication skills are essential, along with the ability to work effectively on matrix teams.
PhD in Chemistry, Biochemistry or related discipline with at least 5 yrs of laboratory experience in metabolite identification within the pharmaceutical industry. Bachelor or Masters degree in Biochemistry, Biology, Chemistry or related discipline with equivalent experience will also be considered.
Hrs per Wk: 40.00
Hrs per Dy: 8.00
A10 - 2 years ago