EMD Serono is the biopharmaceutical division of Merck KGaA, Darmstadt, Germany, a global pharmaceutical and chemical group. We strive to create value and benefit patients by transforming medical science into breakthrough solutions in our core therapeutic areas of neurodegenerative diseases, fertility and metabolic endocrinology, as well as oncology and autoimmune/inflammatory diseases as emerging areas of expertise.
PURPOSE OF THE ROLE
The Protein Engineering and Antibody Technology department is seeking a talented and innovative scientist to join the Antibody Technologies group in Billerica for the development of therapeutic antibodies. The successful candidate will design and execute independent research toward the isolation and screening of B cells from immunized animals. He/she will have a strong background in immunology, broad knowledge and deep understanding of the mechanism of the induction of antibody immune response. The candidate will be responsible for designing, developing and troubleshooting new methods to increase immune response in rodents and independently performing sorting of specific lymphocyte population. The successful candidate will also develop automated assays to assess functionality of antibody. This is a laboratory-based position.
INTERNAL WITHIN EMD SERONO:
The candidate will primarily interact with other members of the Protein Engineering and Antibody Technology department located in Billerica and Darmstadt.
KEY TASKS & RESPONSIBILITIES
- Demonstrated ability to independently design immunization and sorting of cell population strategies and binding assay (such as ELISA or FRET)
- Perform multi-color cell staining for flow cytometry analysis
- Develop and optimize new methods for B cell sorting
- Initiate and champion new immunization strategies to break tolerance according to animal welfare guidelines
- Design and perform animal immunizations, bleeding and tissue collections
- Develop and optimize cellular assays for high-throughput functional hit screening
- Generate, compile, analyze and present data in a clear, concise and highly organized manner
- Assist in optimizing automated methods for antibody cloning and screening
- Work with minimal supervision
EDUCATION & LANGUAGES
Ph.D. in immunology or molecular cellular biology with 0-3 years industry/post-doctoral experience or M.S. with 5+ years of relevant industry experience
Fluent in written and spoken English
PROFESSIONAL SKILLS & EXPERIENCE
Strong expertise with multi-color flow cytometry analysis. Experience in cell sorting is a plus.
In-depth knowledge of rodent immune system and immunization methods
Experience with mammalian tissue culture and transfection, immunoassay development, molecular biology
Experience with basic molecular biology and biochemistry techniques, including PCR, cloning, Western Blot, ELISA, FRET
Direct experience and knowledge of the design, optimization of cellular assays
Experience with automation is preferred
Highly motivated with ability to generate detailed written records and reports of the work accomplished in a timely manner
PERSONAL SKILLS & COMPETENCIES
Ability to work in an intense, fast paced and team environment
Strong oral and written communication skills
Strong organization and time management
Strong data analysis and problem-solving skills
Ability to multitask
Ability to work independently or as a team member
Normal and routine laboratory duties
Equal Employment Opportunity
The Company is an Equal Employment Opportunity employer.
No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, or any other classification protected by applicable federal, state, or local law.
This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment.
Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to his/her Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because he/she made a good faith report of discrimination.
EMD Serono - 9 months ago