Shire - Lexington, MA

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Primary Duties:

The primary role of this position is to support Research projects and the Proof-of-Concept studies by designing and conducting molecular biology and cell biology experiments to over express recombinant proteins, and to characterize recombinant proteins with in vitro experiments. The responsibilities of this role include planning, designing and execution of scientific experiments using molecular and cell biology methodologies; interpreting and presenting scientific data. Success in this role is measured by the ability to conduct literature research, to provide strategically relevant and scientifically reliable information that supports the Company’s goals. No managerial responsibility and no budgetary responsibility are required for this role. A good candidate should have an excellent team oriented spirit that is demonstrated by working toward common business goals with fellow scientists, being flexible with assignments and adaptable to the changing needs of projects. This person must be self-motivating and hard-working. Attention to detail is required.


70% Research Activities including experimental planning and direct laboratory activities, relevant and necessary literature review.

20% Communicating with supervisor and colleagues in the group regarding experimental designs and results.
10% Report writing and record keeping.

Education and Experience Requirements:

A Ph.D. in Life Sciences with emphasis on Molecular Biology or Cell Biology, and with five years of relevant working experience. Industrial experience is preferred.

Key Skills, Abilities, and Competencies:

Knowledge in molecular cloning and cell line development, experience in the relevant methodology, such as DNA cloning, PCR, DNA ligation and transformation. Capability in designing expression constructs for mammalian, baculo-virus or bacteria expression system, performing transfection and transformation to overexpress recombinant proteins, evaluating the productivity of cell lines by biochemical methodology such as ELISA, enzyme activity assay and Western blot analysis. Knowledge and capability in designing and developing new in vitro methods to characterize biomolecules, such as protein, DNA or RNA.
Clear and fluent verbal and written communication skills are required for frequent interaction with supervisor and fellow scientists about experimental design and data, keeping good scientific record, writing reports and giving updates in team meetings.

Complexity and Problem Solving:

This person is expected to work independently with modest supervision. This person should demonstrate motivation in pursuing scientific answers; A good candidate should posses the capability of coming up with strategies for experiment designs, demonstrate sound judgment in execution of experiments, demonstrates problem solving and trouble-shooting skills.

Internal and External Contacts:

This position will have frequent contacts with supervisor and with fellow scientists in Biomolecular Research and Technologies group, with scientists in other groups in Research department. This person may be involved in some project team meetings, and involved in contact with outside collaborators and vendors.

Other Requirements:

Compliance to biohazard, radiation hazard and chemical hazard regulation is required.

Shire's Brave culture offers employees with diverse backgrounds the opportunity to enable those with life altering conditions to lead better lives
Shire is an Equal Opportunity and Affirmative Action Employer

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Shire plc (Shire) is a specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its...