Sr. Principal Scientist, Analytical Development
BioPhase Solutions - San Diego, CA

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BioPhase Solutions specializes in recruiting top talented professionals for San Diego's Scientific community. We are currently looking for a Sr. Principal Scientist, Analytical Development to work for a leading San Diego biotechnology company.

Sr. Principal Scientist, Analytical Development

Candidate has a PhD in synthetic organic chemistry with 10 years of industrial experience in medicinal chemistry and drug discovery with a track record of significant achievement. The candidate should have an extensive knowledge of compound design and lead optimization, as well as a thorough knowledge of contemporary synthetic organic chemistry. The candidate will be responsible for generating innovative and optimized compound designs for multiple projects. The candidate is expected to have extensive knowledge and experience in synthetic chemistry, compound design, drug-like property space, data and trend visualization, lead identification/optimization and SAR analysis. She/he will actively participate in all aspects of drug discovery programs and is expected to have significant understanding of in vitro and in vivo pharmacology, pharmacodynamics and pharmacokinetics principles, ADMET concepts, discovery safety, and pharmaceutical properties.

Responsibilities will include, but are not limited to the following:

Design, optimize and propose syntheses for small molecule inhibitors based on multi-dimensional analysis including physicochemical properties, SAR, SBDD, FBDD, DMPK, safety, and/or pharmacology data aligned to project goals

Visualize and evaluate data and provide impactful hypotheses for the design and optimization of novel, drug-like chemical entities

Successfully apply multivariate analysis to resolve project issues

Balance compound properties, identify property issues and propose solutions

Deliver compound and library designs and synthetic approaches for multiple projects

Effectively work with chemistry teams and provide input on team tactics and strategy by applying state-of-the-art modeling and informatics approaches

Provide scientific leadership in solving property/design issues for multiple target and project teams

May coordinate external chemistry strategies

Impactful interaction on a multi-disciplinary project teams

May serve as a project leader

May supervise individuals or a team

Hands-on synthetic chemistry knowledge and problem solving

May manage external collaborations and CRO’s.

Skills/Knowledge Required:
Extensive synthetic chemistry expertise with a proven track-record on small molecule drug discovery projects as evidenced by project impact, publications and patents

Expert level of experience in modern medicinal chemistry and drug discovery techniques (including lead identification/optimization, FBDD, SBDD, multivariate analysis and visualization tools)

Expert knowledge in applying the state-of-the-art molecular modeling and chemoinformatics to drug discovery

Extensive experience with data mining and chem-/bioinformatics software such as Seurat, Dotmatics, HEOS, Spotfire, Pipeline Pilot, etc.

Expert knowledge of protein dynamics and compound molecular properties

High level of knowledge of drug discovery targets, biochemistry, pharmacology, DMPK, discovery safety, and pre-clinical development

Expert level ability in literature searching using common chemical and literature databases such as SciFinder, MedLine, etc.

Knowledge of IP-related issues

Able to assimilate ideas from multiple sources including the patent and scientific literature

A working knowledge of structural alerts, chemical stability, compound liabilities, organic chemistry, and synthetic do-ability

Knowledge of the pharmaceutical industry and clinical development process

Excellent oral and written communication skills

Effective team building and teamwork skills

Detail-oriented with the ability to identify and implement creative solutions
Ability to prioritize and manage time efficiently

Strong interdisciplinary interaction skills

Project leadership experience

BioPhase Solutions - 15 months ago - save job
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