BioPhase Solutions specializes in recruiting top talented professionals for San Diego's Scientific community. We are currently looking for a Sr. Principal Scientist, Analytical Development to work for a leading San Diego biotechnology company.
Sr. Principal Scientist, Analytical Development
Candidate has a PhD in synthetic organic chemistry with 10 years of industrial experience in medicinal chemistry and drug discovery with a track record of significant achievement. The candidate should have an extensive knowledge of compound design and lead optimization, as well as a thorough knowledge of contemporary synthetic organic chemistry. The candidate will be responsible for generating innovative and optimized compound designs for multiple projects. The candidate is expected to have extensive knowledge and experience in synthetic chemistry, compound design, drug-like property space, data and trend visualization, lead identification/optimization and SAR analysis. She/he will actively participate in all aspects of drug discovery programs and is expected to have significant understanding of in vitro and in vivo pharmacology, pharmacodynamics and pharmacokinetics principles, ADMET concepts, discovery safety, and pharmaceutical properties.
Responsibilities will include, but are not limited to the following:
Design, optimize and propose syntheses for small molecule inhibitors based on multi-dimensional analysis including physicochemical properties, SAR, SBDD, FBDD, DMPK, safety, and/or pharmacology data aligned to project goals
Visualize and evaluate data and provide impactful hypotheses for the design and optimization of novel, drug-like chemical entities
Successfully apply multivariate analysis to resolve project issues
Balance compound properties, identify property issues and propose solutions
Deliver compound and library designs and synthetic approaches for multiple projects
Effectively work with chemistry teams and provide input on team tactics and strategy by applying state-of-the-art modeling and informatics approaches
Provide scientific leadership in solving property/design issues for multiple target and project teams
May coordinate external chemistry strategies
Impactful interaction on a multi-disciplinary project teams
May serve as a project leader
May supervise individuals or a team
Hands-on synthetic chemistry knowledge and problem solving
May manage external collaborations and CROâ€™s.
Extensive synthetic chemistry expertise with a proven track-record on small molecule drug discovery projects as evidenced by project impact, publications and patents
Expert level of experience in modern medicinal chemistry and drug discovery techniques (including lead identification/optimization, FBDD, SBDD, multivariate analysis and visualization tools)
Expert knowledge in applying the state-of-the-art molecular modeling and chemoinformatics to drug discovery
Extensive experience with data mining and chem-/bioinformatics software such as Seurat, Dotmatics, HEOS, Spotfire, Pipeline Pilot, etc.
Expert knowledge of protein dynamics and compound molecular properties
High level of knowledge of drug discovery targets, biochemistry, pharmacology, DMPK, discovery safety, and pre-clinical development
Expert level ability in literature searching using common chemical and literature databases such as SciFinder, MedLine, etc.
Knowledge of IP-related issues
Able to assimilate ideas from multiple sources including the patent and scientific literature
A working knowledge of structural alerts, chemical stability, compound liabilities, organic chemistry, and synthetic do-ability
Knowledge of the pharmaceutical industry and clinical development process
Excellent oral and written communication skills
Effective team building and teamwork skills
Detail-oriented with the ability to identify and implement creative solutions
Ability to prioritize and manage time efficiently
Strong interdisciplinary interaction skills
Project leadership experience
BioPhase Solutions - 15 months ago