Sr. Scientist/Principal Scientist Molecular Discovery (2
Pfizer Inc. - La Jolla, CA

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Org Marketing Statement
Pfizer Inc: Working together for a healthier world

Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide.

Role Description
Pfizer Worldwide Research and Development La Jolla, have two open positions for talented and creative research scientists in the Structural Biology Group, Department of Cancer Research Chemistry. The successful candidates will have significant experience in a number of sub-disciplines of structural biology and their applications to structure based drug design and protein science aspects of drug discovery projects. We are particularly interested in candidates who have demonstrated an ability to apply innovative and high quality research to answer challenging and unprecedented structural biology and protein science questions and who desire to apply these abilities to challenging targets in the oncology therapeutic area. Experience in signal transduction structural biology and biochemistry would be an advantage. The positions will be filled at the level of Senior Scientist or Principal Scientist.

Position 1 will primarily focus on the following areas: 1) crystallization and iterative co-crystallization of oncology protein targets with small molecules to drive SBDD platforms. 2) design of protein crystallization constructs using bioinformatics resources and homology model building. 3) biophysical characterization (e.g. ITC, SPR, AUC, DSC) of proteins and protein-ligand complexes to facilitate protein crystallization and protein science studies. 4) protein purification.
Position 2 will primarily focus on the following areas: 1) x-ray data collection and structure determination of ligand bound precedented and novel targets. 2) biophysical characterization (e.g. SAXS, ITC, SPR, AUC, DSC) of proteins and protein-ligand complexes to facilitate protein crystallization and protein science studies. 3) crystallization and iterative co-crystallization of oncology protein targets with small molecules to drive SBDD platforms


Candidates will possess the following skills:
Excellent oral and written communication skills and good presentation skills.
Excellent interpersonal skills which facilitate knowledge sharing and scientific discussions.
Ability to quickly and effectively operate, communicate and influence decision making within cross-functional and multi-disciplinary teams comprising; biochemists, biologists, chemists, crystallization scientists, protein scientists and x-ray crystallographers.

Applicants will have the following minimum requirements, PhD and Postdoctoral experience in Structural Biology, Biochemistry or a closely related field. 3-5 years of drug discovery experience in Biotechnology or Pharmaceutical sectors would be an advantage.

Equal Employment Opportunity
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Pfizer in the U.S. In certain circumstances it may be advantageous to Pfizer to support the application(s) for temporary visa classification and/or sponsor applications for permanent residence so that a foreign national colleague can accept or remain in a work assignment in the U. S. For certain classes of temporary visas, the resulting work authorization may be specific to Pfizer and the specific job and/or work site. Pfizer may at its business discretion decide to or refrain from obtaining, maintaining and/or extending the temporary visa status and/or sponsoring a colleague for permanent residency and /or employment eligibility, considering factors such as availability of qualified U.S. workers and the colleague's long-term prospects for securing lawful permanent residence, among other reasons. Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work for Pfizer in the U.S. and, if so, whether that authorization permits them to work in the job they seek. In no case should Pfizer's support of a colleague's temporary visa application or sponsorship of a colleague for permanent residence be construed to guarantee success of that application or amend or otherwise invalidate the "at-will" employment relationship between the colleague and Pfizer.

Pfizer Inc. - 3 years ago - save job
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Pfizer pfabricates pfarmaceuticals pfor quite a pfew inpfirmities. The company is the world's largest research-based pharmaceuticals...