Job ID: 13768
Location: Summit, NJ
Full/Part Time: Full-Time
Department: Translational Medicine - 3268
Celgene Corporation is committed to delivering innovative therapies designed to improve the lives of patients worldwide. We are a global biopharmaceutical company with operations in more than 70 countries that is helping to turn incurable cancers into chronic, manageable conditions. We are seeking talented professionals as we continue to grow and advance our efforts in oncology, hematology and immune and inflammatory disease. If you would like to join a company where you can make a difference, please consider the Celgene family.
Requirements & Education:
Translational Development at Celgene
- PhD (Scientific discipline)
- 10 years industry experience
The role of translational development at Celgene is to provide fully integrated functions that bridges our discovery efforts and clinical development. To enable this, Translational Development will engage with discovery project teams to support target selection and disease area strategies, provide leadership for early clinical programmes from CD nomination to proof of principle (i.e., Phase 2A) studies. In order to facilitate this, Translational Development will be integrated into Early Development Teams that will cost effectively and rapidly move the portfolio through early safety, efficacy and signal searching studies and ultimately hand over provide a robust roadmap for registration to the late development or Brand Teams. The Translational Development group is responsible for working with discovery to develop target validation approaches, define appropriate disease models for clinical studies, early engagement with discovery and early development team for biomarker maker development, defining patient selection strategies, and clinical pharmacology to define starting doses and schedules for dose escalation in Phase 1 studies. In addition rational design of combination of novel molecules which challenge the current treatment paradigms will be encouraged. There is a close working relationship with toxicology.
The candidate will be responsible for both therapeutic areas: Oncology and Inflammation & Immunology.
- Collaborations that impact all of research, or even across multiple functions.
- Scientific and technical expert.
- Proven track record of success in drug discovery and development.
- Cell panel screening: define resistance mechanisms, sensitivity elements, PD markers and potential biomarkers of response
- Genomics analysis from human clinical samples, cell screen samples and clinical trial support (defined clinical experiments from the development teams). This includes development of a high dimensional bioinformatics.
- Clinical PD or Biomarker assays, translated from discovery (if applicable or appropriate) or developed specifically for early clinical use, assessing feasibility and applicability for companion diagnostics
- Application of model systems (in collaboration with the disease biology and in vivo pharmacology groups) beyond those routinely employed by discovery teams that aid in patient stratification/response and compound use, either in-house or as a collaboration
- Translational Development representation to the Development Project teams
- Participate in formulating disease area strategy for target selection and validation
- Evaluating, in conjunction with BD and the established teams, the potential in-licensing opportunities that may include potential therapeutics, emerging technologies, processes or capabilities that will enhance our Drug Discovery and Early Development efforts.
- Being part of the team responsible for establishing key alliances with academic centers, co-operative groups and government agencies for cost effective implementation of Celgene’s R & D and early development strategy
- Track record in large and small companies, leading innovative efforts to deploy technologies and assays for enhanced translational capabilities
- Excellent communication, managerial and scientific qualities are expected
- Ability to interact effectively across boundaries using influencing and relationship building skills.
- Competence in analysis and solving of problems, and the ability to prioritize and make tradeoffs to achieve goals.
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.
- A problem solver who creativily and knowledgably transcends departmental function to act as a resource to entire research effort and senior managers in development.
- Identifies issues early and proposes innovative solutions.
- Communicates within the larger organization and external community.
- Provides expert guidance to multi-disciplinary teams and senior management.
- A leader whose scope of influence stretches across Celgene.
- A leader who influences external scientific community.
Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.
Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work in the U.S. and, if so, whether that authorization permits them to work in the job they seek. In no case should Celgene support of a potential employee’s temporary visa application be construed to guarantee success of that application or amend or otherwise invalidate the "at-will" employment relationship between the employee and Celgene.
Celgene is delivering innovative therapies to patients with unmet medical needs in cancer and inflammatory diseases.