Graduate Medical Education (GME): Clinical Chemistry
National Institutes of Health - Bethesda, MD

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Graduate Medical Education (GME): Clinical Chemistry

David B. Sacks, MB, ChB
Entry Id: TP-7

Overview
The Clinical Chemistry Fellowship is a 2-year program providing in-depth training in the various aspects of clinical chemistry. The Clinical Chemistry Service at the NIH performs all the chemical diagnostic testing for the patients in the Clinical Center. The Clinical Center is located on the NIH main campus in Bethesda, Maryland, and supports the intramural research programs of the NIH Institutes and Centers. Patients come from domestic and international locations to participate in research protocols at the Clinical Center, a 240-bed hospital solely dedicated to biomedical research. Animal testing is also conducted in the Clinical Chemistry laboratory. From a menu of about 170 different assays, approximately 180,000 tests are performed per month by a technical staff of 39 medical technologists and chemists. Fellows also spend time at other hospitals in the area.

Clinical Training Program
The first three months of the program are devoted to rotations through various Clinical Chemistry sections: general chemistry, special chemistry, immunoassays, electrophoresis, urinalysis, therapeutic drug monitoring, HPLC and mass spectrometry. The fellow is then expected (on a rotating basis) to handle inquiries to the Clinical Chemistry Service from patient-care physicians and is encouraged to attend working patient rounds. Throughout the training, special emphasis is placed on the correlation of laboratory data with the status of patients in the Clinical Center. After the initial training, the fellow regularly works up and presents patient cases and has an opportunity to participate in translational research.

Research Training Program
During the first 3 months of the program the fellow meets with and discusses the research and service responsibilities of each Senior Staff member. The fellow is encouraged to choose a research project for independent investigation under the supervision of a Senior Staff member, or to participate in an ongoing research project. The fellow is also responsible for developing one or two methods for implementation by the Clinical Chemistry Service. The project for method development is determined by the needs of the Service at the time. Members of the Clinical Chemistry Service collaborate with clinicians in clinical research and conduct their own independent research. An important new initiative in the service is mass spectrometry, which is expanding in both clinical and research applications. Numerous opportunities are available to participate in both basic and translational research projects.
Faculty and Clinical Research Interests

David B. Sacks, MB, ChB

HbA1c

Glucose

Biomarkers of diabetes

Intracellular signal transduction

Alan Remaley, MD, PhD

Lipoprotein metabolism

Atherosclerosis

Cardiovascular biomarkers

Steven J. Soldin, PhD

Pharmacology, drug and metabolite studies

Endocrinology, HPLC, Mass Spectrometry

New test development for steroids, thyroid hormones and peptides. Evaluation of these tests in clinically approved protocols.

Zhen Zhao, PhD

General Clinical Chemistry

Endocrinology

Biomarker Development

MicroRNA

Eligibility

Qualified candidates must be U.S. citizens or permanent residents and must have an M.D. and/or Ph.D. Preference is given to individuals who are approximately 2 years beyond the doctoral degree, and who have obtained training in laboratory medicine, clinical medicine, or clinical chemistry. There is one position available each year, usually beginning on July 1st. Applications close on October 1st for positions commencing July 1st of the following year. The expected length of the program is 2 years.
Application Information

Send a letter of interest, curriculum vitae and 3 letters of recommendation to:

David Sacks MB, ChB
Clinical Chemistry Service
Department of Laboratory Medicine
Clinical Center
National Institutes of Health
Building 10, Room 2C-306
10 Center Drive
Bethesda, MD 20892-1508
phone: 301-496-3386
fax: 301-402-1885
Email: david.sacks2@nih.gov

The NIH is dedicated to building a diverse community in its training and employment programs.

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