Epigenetic Regulation of Pre-mRNA Splicing
National Institutes of Health - Bethesda, MD

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Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD and surrounding area

Position Description:
A post-doctoral position is available in the RNA Processing in Cellular Development Section, to study the relationship between chromatin structure and alternative pre-mRNA splicing. The broad goal of the laboratory is to examine whether distinct chromatin signatures or DNA methylation impact splice site choice through modulation of RNA polymerase II elongation and/or splicing factor recruitment. These and related questions will be examined in primary lymphocyte cultures, both genome-wide and within the model system of developmentally-regulated CD45 alternative splicing.

Applicants must be strongly motivated, possess a Ph.D. or equivalent and have no more than three years of post-doctoral experience. Individuals with a background in RNA biochemistry, chromatin biology and in vitro differentiation of lymphocytes are especially encouraged to apply. Candidates with experience in bioinformatic analysis of ChIP-seq and RNA-seq data will also be considered.

Interested individuals should send a statement of research interests, curriculum vitae including bibliography, and contact information for three references by email to:

Dr. Shalini Oberdoerffer
RNA Processing in Cellular Development
Laboratory of Receptor Biology and Gene Expression, CCR, NCI
Bethesda, MD
shalini.oberdoerffer@nih.gov

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.
Epigenetic Regulation of Pre-mRNA Splicing
Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD and surrounding area

Position Description:
A post-doctoral position is available in the RNA Processing in Cellular Development Section, to study the relationship between chromatin structure and alternative pre-mRNA splicing. The broad goal of the laboratory is to examine whether distinct chromatin signatures or DNA methylation impact splice site choice through modulation of RNA polymerase II elongation and/or splicing factor recruitment. These and related questions will be examined in primary lymphocyte cultures, both genome-wide and within the model system of developmentally-regulated CD45 alternative splicing.

Applicants must be strongly motivated, possess a Ph.D. or equivalent and have no more than three years of post-doctoral experience. Individuals with a background in RNA biochemistry, chromatin biology and in vitro differentiation of lymphocytes are especially encouraged to apply. Candidates with experience in bioinformatic analysis of ChIP-seq and RNA-seq data will also be considered.

Interested individuals should send a statement of research interests, curriculum vitae including bibliography, and contact information for three references by email to:

Dr. Shalini Oberdoerffer
RNA Processing in Cellular Development
Laboratory of Receptor Biology and Gene Expression, CCR, NCI
Bethesda, MD
shalini.oberdoerffer@nih.gov

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.

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