Postdoctoral Position in Cellular and Molecular Biology of Signal Transduction
Boston University School of Medicine & Boston Medical Center - Boston, MA

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Postdoctoral Position in Cellular and Molecular Biology of Signal Transduction Boston University, Department of Biochemistry http://www.bumc.bu.edu/biochemistry/
Contact: Mikel Garcia-Marcos, PhD. Assistant Professor mgm1@bu.edu

BACKGROUND : Our lab is interested in understanding how dysregulation of heterotrimeric G protein signaling underlies the molecular basis of disease. We are actively pursuing the identification and characterization of a novel family of non-receptor G protein activators. This mechanism represent a detour form the classical GPCR -mediated pathways. More details about our research can be found at http://www.bumc.bu.edu/biochemistry/people/faculty/mikel-garcia-marcos/ .

The project will consist of carrying out a genome-wide screen to identify members of a new family of G protein activators and subsequently characterize their biological functions.

REQUIREMENTS : We are seeking highly motivated candidates with a recent PhD in the field of Cellular and Molecular Biology of Signal Transduction. The candidate must have a strong commitment to science and be able to work under pressure in a fast paced and very demanding research environment.

The ideal candidate should have a strong background in Biochemistry, Molecular Biology and Cell Biology applied to signal transduction. We are specifically seeking candidates with experience in:
• Structure-guided biochemical analysis of protein-protein interactions (advanced cloning, protein purification, pulldown and fluorescence polarization assays, structure analysis, etc)
• Yeast model system (genetic manipulations, biochemical assays)
• Bioinformatics (computational methods for protein sequence motif searches and analyses).
• Cell biology with mammalian cells (establishing cell lines, signaling assays, immunofluorescence, immunoprecipitation, etc).
• Previous experience in the field of heterotrimeric G protein signaling will be positively evaluated.
Ability to work as a team player and good communication skills are also expected.
Boston University School of Medicine is located in the heart of Boston, a city with an unparalleled scientific and cultural environment for young scientists. The Department of Biochemistry is characterized by a collegial and highly collaborative atmosphere.
Interested candidates should send a CV, including contact information for at least 3 letters of reference, and a short statement describing current situation and background, future goals and reasons for the interest in this position to mgm1@bu.edu . Candidates will be contacted directly if further information is required.
TIMELINE : Acceptance of applications until June 30th. Start date August or as soon as possible.
RELATED LITERATURE :
1. Garcia-Marcos, M., Ghosh, P., & Farquhar, M. G. (2009) GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. Proc Natl Acad Sci USA 106: 3178-3183.
2. Ghosh, P., et al. (2010) A G{alpha}i- GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell 21: 2338-2354.
3. Garcia-Marcos, M., Ear, J., Farquhar, M. G., & Ghosh, P. (2011) A GDI (AGS3) and a GEF ( GIV ) regulate autophagy by balancing G protein activity and growth factor signals. Mol Biol Cell 22: 673-686.
4. Garcia-Marcos, M., et al. (2012) Functional characterization of the guanine nucleotide exchange factor ( GEF ) motif of GIV protein reveals a threshold effect in signaling. Proc Natl Acad Sci USA
5. Garcia-Marcos, M., et al. (2011) Expression of GIV /Girdin, a metastasis-related protein, predicts patient survival in colon cancer. Faseb J 25: 590-599.
6. Ghosh, P., Garcia-Marcos, M., & Farquhar, M. G. (2011) GIV /Girdin is a rheostat that fine-tunes growth factor signals during tumor progression. Cell Adh Migr 5: 237-248….

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