Chromatin-Directed DNA Repair and Its Consequences for Cell Function
National Institutes of Health - Bethesda, MD

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Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD and surrounding area

Two positions are available in the Epigenetics of DNA Repair and Aging Section in the Laboratory of Receptor Biology and Gene Expression. The main interest of our laboratory is to understand how DNA damage and its repair affect the (epi-)genome, and how these changes impinge on nuclear function, genome stability and age-related organ decline. We have recently identified a novel chromatin module that represents an unanticipated aspect of DSB repair pathway choice and may have implications both for tumorigenesis and epigenetic integrity following DNA damage. Current projects focus on (i) a possible link between (tumor) cell metabolism and DNA repair via modulation of said chromatin module, and (ii) the impact of DNA breaks on three-dimensional chromatin structure and associated epigenetic changes in vitro and in vivo.

Candidates should have a Ph.D. or equivalent and no more than five years of post-doctoral experience. Individuals with a strong background in molecular biology and experience with chromatin biology are encouraged to apply. Expertise in bioinformatics, deep sequencing and/or image analysis is an additional asset. Qualified candidates should have strong communication skills and a demonstrated record of scientific achievement through peer-reviewed publications. Successful, well-motivated candidates will join a highly interactive, interdisciplinary team of researchers with diverse backgrounds and expertise in a collaborative scientific environment. Interested individuals should send a two-page statement of research interests, a curriculum vitae and bibliography, and three letters of reference to:

Dr. Philipp Oberdoerffer
Email: Philipp.Oberdoerffer@nih.gov

Current address:
Frederick National Lab
1050 Boyles St, Bldg 560, Room 32-40B
Frederick, MD 21702

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.
Chromatin-Directed DNA Repair and Its Consequences for Cell Function
Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD and surrounding area

Two positions are available in the Epigenetics of DNA Repair and Aging Section in the Laboratory of Receptor Biology and Gene Expression. The main interest of our laboratory is to understand how DNA damage and its repair affect the (epi-)genome, and how these changes impinge on nuclear function, genome stability and age-related organ decline. We have recently identified a novel chromatin module that represents an unanticipated aspect of DSB repair pathway choice and may have implications both for tumorigenesis and epigenetic integrity following DNA damage. Current projects focus on (i) a possible link between (tumor) cell metabolism and DNA repair via modulation of said chromatin module, and (ii) the impact of DNA breaks on three-dimensional chromatin structure and associated epigenetic changes in vitro and in vivo.

Candidates should have a Ph.D. or equivalent and no more than five years of post-doctoral experience. Individuals with a strong background in molecular biology and experience with chromatin biology are encouraged to apply. Expertise in bioinformatics, deep sequencing and/or image analysis is an additional asset. Qualified candidates should have strong communication skills and a demonstrated record of scientific achievement through peer-reviewed publications. Successful, well-motivated candidates will join a highly interactive, interdisciplinary team of researchers with diverse backgrounds and expertise in a collaborative scientific environment. Interested individuals should send a two-page statement of research interests, a curriculum vitae and bibliography, and three letters of reference to:

Dr. Philipp Oberdoerffer
Email: Philipp.Oberdoerffer@nih.gov

Current address:
Frederick National Lab
1050 Boyles St, Bldg 560, Room 32-40B
Frederick, MD 21702

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.

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