Formulation Scientist / Senior Associate Scientist
Pfizer Inc. - Cambridge, MA

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Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide.

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This formulation Research Scientist will support early screening through preclinical stage of delivery formulations for oligonucleotide therapeutics. This scientist will perform hands-on laboratory experiments for developing/executing characterization methods to determine the physicochemical property, purity, stability, degradation rate and pathways of formulations consisting of multicomponents such as oligonucleotides, peptides, polymers, lipids, and proteins.

Develop/validate characterization methods in support of formulation development for nucleic acid-based therapeutics. These methods include but are not limited to HPLC (RP, SEC, IEC), Charged Aerosol Detection, LC/MS, DLS, Electrophoresis, Differential Scanning Calorimetry, Isothermo Titration Calorimetry, Florescence technology, etc.

Determine purity, composition, stability, degradation rate, and degradation pathway of formulated products; characterize the physicochemical properties of the formulations such as morphology, thermo phase transition profile, particle size, particle charge, etc.

Analyze and document detailed results; Provide timely and conclusive reports to the team for decision making.

Self-motivated scientist holding B.S degree in Chemistry, Biochemistry or Pharmaceutical Science related majors with more than 5 years experience or M.S degree with more than 3 years work experience in formulation research and development; Extensive hands-on technical skills in chromatography, and physicochemical characterizations of solutions and nanoparticles. Demonstrated work skills in problem solving, team player, and time management.

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Pfizer Inc. - 3 years ago - save job - block
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