The post-doctoral researcher will be heavily involved in formulation development of early stage protein, peptide, nucleic acid, and nanoparticle-based therapeutics. Responsibilities would include (pre)formulation characterization, screening, and investigational studies, early development of analytical methods, and other biophysical analyses. Additionally, the individual would collaborate with other groups in Process Development (e.g. purification and analytical), and Manufacturing and Contract Manufacturing Organizations (CMOs) to develop scalable formulation processes for both Drug Substances and Drug Products throughout the product development life cycle. Shire offers a state of the art pharmaceutical development laboratory. The successful candidate will have the opportunity to learn about the product development process required to bring products into the clinic and commercial market.
The main job duty will be hands-on laboratory-based activities. Approximately 80% of this individual’s time will be spent executing experiments in the laboratory. The remainder will be distributed between authorship of reports, protocols, and manuscripts as well as presentation at team and department meetings (20%).
Education & Experience Requirements:
Essential: A Ph.D. in Pharmaceutical Sciences, Chemistry, Chemical Engineering or closely related disciplines is essential. This individual should have effective written and verbal communication skills, and a track record of creativity and scientific excellence (evident in their presentation and related publications).
Desired: Some relevant experience in a biotechnology/pharmaceutical environment is desired. General knowledge of cGMP, ICH requirements, and lyophilization technology is highly desirable.
Key Skills and Competencies:
• Work is performed under general guidance but is highly autonomous: the individual will plan and conduct research projects and receives general instructions while working collaboratively with the members of the DPD.
• The individual is highly encouraged to develop new ideas to solve challenging problems.
• The individual should have general protein, peptide, nucleic acid, and nanoparticle analysis skills.
• Team work to solve challenging problems is highly encouraged.
Build on Integrity: Act with integrity in all you do. Be forth right in a way that builds sustained relationships. Demonstrate respect for the individual, diversity and the environment
Risk a “Risk”: Believe in your convictions; anything is possible! Take measured risks and create innovative solutions that make a difference.
Act on the Needs of Patients: With relentless dedication, serve our patients in everything you do. Create a quality customer experience for those you interact with.
Vie to Be Better Than Yesterday: Demonstrate a true sense of urgency and don't make great ideas wait. Make progress everyday to avoid the complacency that prior success may bring.
Exemplify Trust & Openness: Trust your colleagues and draw on their input for better outcomes. Collaborate across boundaries and geographies. Build openness through teamwork and focus on tackling business challenges.
Complexity and Problem Solving:
Daily scientific decisions are made by the incumbents; the decisions should involve discussions/communications with the mentor and DPD Team.
Internal and External Contacts:
The mentor and other members of the Pharmaceutical and Process Development Team, and potentially contract analytical facilities are the main interactions for this position.
The individual will be accountable to deliver the results in a timely manner to the mentor and the management team.
Shire's Brave culture offers employees with diverse backgrounds the opportunity to enable those with life altering conditions to lead better lives
Shire is an Equal Opportunity and Affirmative Action Employer
Shire - 22 months ago
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Shire plc (Shire) is a specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its...