A postdoctoral position is available in the Department of Physiology at UCLA to study the physiological role and molecular mechanism of calcium signalling in the immune response. Research interests involve understanding the role of calcium signalling in diverse immune cells using genetically modified mice and various animal models of human disease. Experience in basic cell culture, molecular biology, flow cytometry, analyses of autoimmune disease models, and mouse-handling techniques are required. Recent PhD graduates with a strong background of studying immunity and/or bioinformatics will be preferred. Interested applicants should send a cover letter explaining relevant work experience (less than 2 pages), curriculum vitae and contact details of three referees by e-mail.
Please visit our web site for a brief overview of our work. http://www.physiology.ucla.edu/faculty/gwack.html
Gwack Y et al. A genome-wide Drosophila RNAi screen identifies DYRK as a novel regulator of NFAT . Nature (letter), 2006 Jun 1;441(7093): 646-50.
Feske S et al. A mutation in Orai1 causes immune deficiency by abrogating store-operated Ca2+ entry and CRAC channel function, Nature (Article), 2006 May 11;441(7090): 179-85.
Prakriya M et al. Orai1 is an essential component of the CRAC channel pore, Nature (letter). 2006 Sep 14;443(7108): 230-3.
Srikanth S et al. A novel EF hand-containing protein, CRACR2A is a cytosolic Ca2+ sensor that stabilizes active conformation of the CRAC channel. Nature Cell Biology (article), 2010 May; 12(5): 436-446.
Kim KD, Srikanth S, Yee MK, Mock DC, Lawson GW, Gwack Y. ORAI1 deficiency impairs activated T cell death and enhances T cell survival. Journal of Immunology, 2011, Oct; 187(7): 3620-30.
Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y. Junctate is a Ca2+-sensing structural component of Orai1 and STIM1 clustering site at the proximal plasma membrane. PNAS , 2012, May 29; 109(22): 8682-7.
Nature Jobs - 12 months ago