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Graduate Medical Education (GME): Allergy and Immunology
NIAID Basic and Clinical Research Training
Allergy and Immunology Training Program
Kelly D. Stone, MD, PhD, Program Director
Dean D. Metcalfe, MD, Associate Program Director
The National Institute of Allergy and Infectious Diseases (NIAID) offers a three-year, ACGME-accredited training program in allergy and immunology. This program, open to physicians who are well-grounded in clinical internal medicine or pediatrics, is designed to provide trainees with the high-quality clinical and laboratory skills that will enable them to pursue careers in academic medicine.
Structure of the Clinical Training Program
The majority of the first year of training is dedicated to clinical activities, with intensive exposure to the broad spectrum of allergic and immunologic diseases in children and adults. Clinical rotations covering outpatient and inpatient aspects of the specialty are completed at the National Institutes of Health (NIH) Clinical Center (outpatient clinics, inpatient ward, allergy and immunology consultation service, and pulmonary function lab), the Walter Reed Army Medical Center, the Children's National Medical Center, the Johns Hopkins Pediatric Allergy Clinic, and a local practice.
Patients seen at NIH under research protocols have a wide variety of disorders, including allergic diseases, asthma, inherited and acquired immunodeficiencies, mast cell disorders (including mastocytosis), idiopathic eosinophilias, autoimmune diseases, and HIV/AIDS. In addition, fellows in training are the allergy and immunology consultants for the NIH Clinical Center and rotate through the NIH diagnostic immunology laboratory, the pulmonary function laboratory in the National Heart, Lung, and Blood Institute (NHLBI), and the adult asthma clinic of the NHLBI.
In the second year, fellows are engaged in both clinical care (limited continuity clinics and consultation service) and in research. The third year of training is devoted exclusively to research. Fellows have the option, with approval, for a fourth and occasionally a fifth year of research training.
Fellows also receive broad instruction in allergic and immunologic disorders and attend conferences designed to prepare trainees for the American Board of Allergy and Immunology (ABAI) examination. Conferences include a basic and clinical immunology lecture series, case conferences, journal clubs, and NIAID Grand Rounds. Fellows are generally fully qualified to take the ABAI certification examination after two years in the program.
Structure of the Research Training Program
The core of this clinical fellowship program is the effort devoted to research training and performance of original basic, translational, and/or clinical research. Fellows work under the direct supervision and mentorship of senior NIAID investigators. The research experience is characterized by close daily contact with the preceptor, individual instruction, and continuity during the training period. The goal of the research training is to provide a productive experience leading to the development of successful independent investigators.
Fellows work in the laboratory and/or perform clinical research for about ten percent of the time during the first year, 60 percent in the second year, and exclusively in the third year. Allergy and immunology fellows may request to work in any of the laboratories within the intramural NIAID program . Research opportunities involve a wide range of investigations in various aspects of allergy and immunology. These vary from clinical to the most basic aspects of cell and molecular biology. Trainees have pursued research projects in the following areas:
The biology of the mast cell, basophil, and eosinophil
Pathophysiology and treatment of anaphylaxis and other allergic disorders
Effect of cytokines on cellular responses
Diagnosis of and host responses to infectious agents
Diagnosis, molecular characterization, and treatment of primary immunodeficiency disorders
Biology and treatment of systemic mastocytosis
The role of antibody and cellular immune systems in inflammation and autoimmunity
The function of cellular receptors for immunoglobulin, cytokines, and matrix components
The basis of mucosal immunity
Humoral and cellular immunoregulation and immunoregulatory defects
The biology of polymorphonuclear leukocytes, monocytes, and macrophages
Aspects of the pathogenesis of HIV
Program Faculty and Research Interests
Representative NIH Clinical and Research Faculty
Melody Carter, M.D., Staff Clinician, Laboratory of Allergic Diseases, NIAID, NIH
Anthony Fauci, M.D. , Director, NIAID. and Chief, Laboratory of Immunoregulation, NIAID, NIH
Thomas Fleisher, M.D. , Chief of Laboratory Medicine, NIH Clinical Center
John Gallin, M.D. , Director, NIH Clinical Center. and Chief, Clinical Pathophysiology Section, Laboratory of Host Defenses, NIAID, NIH
Steven Holland, M.D., Chief, Laboratory of Clinical Infectious Diseases, NIAID, NIH
Ashish Jain, M.D., Chief, Clinical Immunology Unit, Laboratory of Host Defenses, NIAID, NIH
Amy Klion, M.D., Chief, Eosinophil Pathology Unit, Laboratory of Parasitic Diseases, NIAID, NIH
Hirsh Komarow, M.D., Staff Clinician, Laboratory of Allergic Diseases, NIAID, NIH
Clifford Lane, M.D., Clinical Director, NIAID. and Chief, Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, NIAID, NIH
Stewart Levine, M.D., Chief, Lung Inflammation Section, National Heart, Lung, and Blood Institute, NIH
Harry Malech, M.D., Chief, Laboratory of Host Defenses, NIAID, NIH
Dean Metcalfe, M.D., Chief, Laboratory of Allergic Diseases, NIAID, NIH
JoAnn Mican, M.D., Staff Clinician, Division of Clinical Research, NIAID, NIH
Joshua Milner, M.D., Chief, Allergic Inflammation Unit, Laboratory of Allergic Diseases, NIAID, NIH
Thomas Nutman, M.D., Deputy Chief, Laboratory of Parasitic Diseases, NIAID, NIH
William Paul, M.D., Chief, Laboratory of Immunology, NIAID, NIH
Calman Prussin, M.D., Chief, Lymphocyte Biology Unit, Laboratory of Allergic Diseases, NIAID, NIH
Koneti Rao, M.D., Chief, ALPS Unit, Laboratory of Clinical Infectious Diseases, NIAID, NIH
Helene Rosenberg, M.D., Ph.D., Chief, Eosinophil Biology Section, Laboratory of Allergic Diseases, NIAID, NIH
Ethan Shevach, M.D., Chief, Cellular Immunology Section, Laboratory of Immunology, NIAID, NIH
Kelly Stone, M.D., Ph.D., Director, Allergy and Immunology Clinical Training Program, Laboratory of Allergic Diseases, NIAID, NIH
Warren Strober, M.D., Chief, Mucosal Immunity Section, Laboratory of Host Defenses, NIAID, NIH
Helen Su, M.D., Ph.D., Chief, Human Immunological Diseases Unit, Laboratory of Host Defenses, NIAID, NIH
Gulbu Uzel, M.D., Staff Clinician, Laboratory of Clinical Infectious Diseases, NIAID, NIH
Todd Wilson, D.O., Staff Clinician, Laboratory of Allergic Diseases, NIAID, NIH Faculty at affiliated training sites
Michael Nelson, M.D., Ph.D., Chief, Department of Allergy and Immunology, Director, Allergy and Immunology Training Program, Walter Reed Army Medical Center
Cecilia Mikita, M.D., Associate Director, Allergy and Immunology Training Program, Walter Reed Army Medical Center
Naynesh Kamani, M.D., Division of Blood and Marrow Transplantation and Immunology, Children's National Medical Center
Brett Loechelt, MD, Division of Blood and Marrow Transplantation and Immunology, Children's National Medical Center
Hemant Sharma, M.D., M.H.S., Division of Immunology, Children's National Medical Center
Robert Wood, M.D., Chief, Division of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine
Elizabeth Matsui, M.D., Division of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine
Michael Kaliner, M.D., Institute for Asthma and Allergy
Mark Scarupa, M.D., Institute for Asthma and Allergy
Examples of papers authored by program fellows and faculty
Zhang Q, Davis JC, Lamborn IT, Freeman AF, Jing H, Favreau AJ, Matthews HF, Davis J, Turner ML, Uzel G, Holland SM, Su HC. Combined immunodeficiency associated with DOCK8 mutations. N Engl J Med . 2009;361(21): 2046-55.
Vinh DC, Patel SY, Uzel G, Anderson VL, Freeman AF, Olivier KN, Spalding C, Hughes S, Pittaluga S, Raffeld M, Sorbara LR, Elloumi HZ, Kuhns DB, Turner ML, Cowen EW, Fink D, Long-Priel D, Hsu AP, Ding L, Paulson ML, Whitney AR, Sampaio EP, Frucht DM, DeLeo FR, Holland SM. Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia. Blood . 2010;115(8): 1519-29.
De Ravin SS, Cowen EW, Zarember KA, Whiting-Theobald NL, Kuhns DB, Sandler NG, Douek DC, Pittaluga S, Poliani PL, Lee YN, Notarangelo LD, Wang L, Alt FW, Kang EM, Milner JD, Niemela JE, Fontana-Penn M, Sinal SH, Malech HL Hypomorphic Rag mutations can cause destructive midline granulomatous disease. Blood. 2010;116(8): 1263-71.
Ogbogu PU, Bochner BS, Butterfield JH, Gleich GJ, Huss-Marp J, Kahn JE, Leiferman KM, Nutman TB, Pfab F, Ring J, Rothenberg ME, Roufosse F, Sajous MH, Sheikh J, Simon D, Simon HU, Stein ML, Wardlaw A, Weller PF, Klion AD. Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy. J Allergy Clin Immunol . 2009;124(6): 1319-25.
Prussin C, Lee J, Foster B. Eosinophilic gastrointestinal disease and peanut allergy are alternatively associated with IL-5+ and IL-5(-) T(H)2 responses. J Allergy Clin Immunol. 2009;124(6): 1326-32.
Bansal G, Xie Z, Rao S, Nocka NH, Druey KM. Suppression of immunoglobulin E-mediated allergic responses by regulator of G-protein signaling 13. Nature Immunol . 2008;9(1): 73-8.
Arthos J, Cicala C, Martinelli E, Macleod K, Van Ryk D, et al. HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. Nature Immun . 2008;9(3): 301-9.
Milner JD, Brenchley JM, Laurence A, Freeman AF, Hill BJ, et al. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature . 2008;452(7188): 773-6.
Akin, C, Scott LM, Kocabas CM, Kushnir-Sukhov N, Brittain E, Noel P, Metcalfe DD. Demontration of an aberrant mast-cell population with clonal markers in a subset of patients with “idiopathic” anaphylaxis. Blood . 2007;110(7): 2331-3.
Holland SM, DeLeo FR, Elloumi HZ, Hsu AP, Uzel G, et al. STAT3 mutations in the hyper-IgE syndrome. N Engl J Med . 2007;357(16): 1608-19.
Representative recent program graduates
Cem Akin, M.D., Ph.D., Assistant Professor, Brigham and Women's Hospital
Princess Ogbogu, M.D., Assistant Professor, Ohio State University
Julie Martin, D.O., Deputy Chief, Clinical Trials Core, Vaccine Research Center, NIAID, NIH
Stefano Luccioli, M.D., Center for Food Safety and Applied Nutrition, FDA
Ashish Jain, M.D., Tenure-Track Scientist, NIAID, NIH
Helen Su, M.D., Ph.D., Tenure-Track Scientist, NIAID, NIH
Joshua Milner, M.D., Tenure-Track Scientist, NIAID, NIH
Brian Porter, M.D., Ph.D., Medical Officer, Division of Pulmonary, Allergy, and Rheumatology Products, FDA
Jennifer Heimall, M.D., Assistant Professor, Children's Hospital of Philadelphia
Benjamin Soule, M.D., Assistant Professor, University of Pennsylvania
The Allergy and Immunology Clinical Fellowship Program is fully accredited by the Accreditation Council for Graduate Medical Education (ACGME). Fellows are eligible to sit for the Board of Allergy and Immunology certification examination after two years.
Candidates are selected through the National Residency Matching Program. There are two to four positions available per year. Candidates should apply for the program in the summer via the ERAS system.
Applications must contain the following:
My ERAS application
Three letters of recommendation
Medical school transcript
Medical student performance evaluation/Dean's letter
USMLE or COMPLEX transcript
ECFMG status report (for international medical graduates only)
Applicants must have completed an ACGME-approved residency in internal medicine or pediatrics by the time they enter the program. Interviews are held August 1-November 1.
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