Molecular Genetics of Endometrial (Uterine) Cancers
National Institutes of Health 5 reviews - Bethesda, MD

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Daphne Bell, Ph.D.

Cancer Genetics Branch

Molecular Genetics of Endometrial (Uterine) Cancers

Department of Health and Human Services

National Institutes of Health

National Human Genome Research Institute

Social and Behavioral Research Branch

The laboratory of Daphne Bell, Ph.D. , within the Cancer Genetics Branch of the National Human Genome Research Institute, is seeking an outstanding Postdoctoral Fellow to characterize the functional significance of somatic mutations present in clinically aggressive cancers of the uterus. Together with the NIH Intramural Sequencing Center, the Bell laboratory is using next generation sequencing to decode the exomes of paired tumor-normal tissues and thus identify somatic mutations present in only the tumor exomes ( Nature Genetics 2012; 44:1310-5). Somatic mutations can either be driver mutations that contribute to tumorigenesis or passenger mutations with no relevance to cancer.

The successful candidate will use molecular, biochemical and cellular approaches to determine the functional significance of frequently mutated genes, and/or frequently mutated pathways, to determine whether they are driver events. Access to extensive core facilities including a flow cytometry core, cytogenetics core, bioinformatics core, and transgenic mouse core, offers the trainee wide latitude in the design and pursuit of their research questions. A demonstrated record of scientific accomplishment in the field of molecular cancer genetics, as well as strong intellectual commitments to cancer research and to the individual research project, are essential.

Applicants must possess good communication skills and be fluent in both spoken and written English. Salary will be commensurate with research experience and is highly competitive. The Intramural Research Program is on the Bethesda, Md. campus and offers a wide array of training opportunities for scientists early in their careers.

Interested candidates should email a CV and cover letter to

Daphne W. Bell, Ph.D.

Head, Reproductive Cancer Genetics Section

Cancer Genetics Branch

National Human Genome Research Institute/NIH

Building 50, Room 5339

50 South Drive, MSC 8000

Bethesda, MD 20892

Phone: (301) 594-9256

Fax: (301) 594-1360

DHHS and NIH are Equal Opportunity Employers and encourage applications from women and minorities.

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Posted: February 1, 2013

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