An Associate Scientist - Cell Biology opportunity is available to join the Conrad Prebys Center for Chemical Genomics (CPCCG) and contribute toward the Center’s chemical biology and drug discovery efforts at the La Jolla campus.
The Cell Biology Associate Scientist will develop novel assays based on induced pluripotent stem cell (iPSC) derived cell types including neurons, cardiomyocytes and hepatocytes, convert into miniaturized 384-well formats, and perform assay automation and implementation on available robotics systems according to input from the HTS team. Assays will primarily be developed using image based, high content analyses.
Will also perform mammalian cell culture including pluripotent stem cells; oversee multiple cell lines simultaneously, differentiate pluripotent stem cells to a variety of lineages, and generate transgenic stable cell lines. Will perform molecular biology and protein analysis (immunoblotting) necessary for cell-based and biochemcial assay development and perform all other related duties and tasks as required or assigned.
Will interpret, evaluate and analyze data, accurately document and record experiments in lab notebooks, and work with their team to present results as needed.
The Associate Scientist will plan and manage all aspects of assigned research projects, independently analyze results in a database-driven environment and formulate conclusions, independently identify and develop solutions to technical problems, and perform other related duties and tasks as required or assigned.
Requires a bachelors degree in a biological science, chemistry, physics or a related field and a minimum of 3 years of directly related experience, or an equivalent combination of education, training and experience from which comparable knowledge, skills and abilities have been attained. Candidates with a masters degree, a minimum of 1 year (and typically up to 3 years) are required. Relevant, hands-on laboratory experience in a drug discovery environment is strongly desired.
Must have demonstrated previous experience and knowledge in cell-based assay development including experience with mammalian cell culture and immunocytochemistry. Requires experience with acquisition and analysis of multi-parametric quantitative experimental data. Molecular biology knowledge and experience with iPSC derived and primary cell types, especially neural cell types, is strongly preferred. Experience in electrophysiology, and/or high content imaging would be a plus.
Requires the ability to work independently as well as a demonstrated ability to work in a highly interactive team within a matrix environment and the ability manage multiple projects in a rapidly changing, deadline-driven environment.
Must have a professional demeanor and excellent verbal, written, interpersonal and organizational skills. Must have professional proficiency in Microsoft Office and the ability to learn department-specific computer systems as needed.
Sanford-Burnham Medical Research Institute is an Equal Opportunity employer–M/F/Veteran/Disability. We are committed to the hiring, advancement and fair treatment of all individuals and all qualified applicants will receive consideration for employment without regarding to race, color, religion, sex, national origin, sexual orientation, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law. For additional information about your rights as an applicant, click HERE .
Sanford-Burnham Medical Research Institute - 30+ days ago