The Cornea Genetics Laboratory ( http://www.jsei.org/aldavelab/ ) at the Jules Stein Eye Institute on the University of California, Los Angeles campus is seeking a highly motivated postdoctoral candidate with strong bioinformatics skills. The lab focuses on identifying the genetic basis of the corneal dystrophies by utilizing classical and cutting-edge technologies. The focus of the research currently conducted in the Cornea Genetics Laboratory is on posterior polymorphous corneal dystrophy ( PPCD ). The candidate will apply integrative genomics and systems biology approaches to identify causal molecular alterations that lead to the development of PPCD . At least two chromosomal loci have been identified as being involved in the pathogenesis of PPCD : the PPCD1 locus on chromosome 20, in which the genetic basis has not yet been identified; and the PPCD3 locus on chromosome 10, in which truncating mutations in ZEB1 have been identified in approximately 1/3 of affected families. Identification of genes that are regulated in a ZEB1-dependent manner will be performed using gene expression arrays and the results will be subsequently validated by cell and molecular biology approaches.
Candidates are expected to hold a Ph.D. or equivalent in bioinformatics, computational biology, statistical genetics or other relevant areas. They are also expected to have a strong interest in working closely with cell and molecular biologists to interpret the complex relationships present among genetic, genomic, and phenotypic data generated from studies involving families with PPCD . A strong computational and bioinformatics background is expected, as is proficiency or familiarity with R/Bioconductor, Pearl, C++, and relational databases (MySQL, Microsoft SQL , etc). A working knowledge of high throughput datasets (gene expression array, genotyping, and/or next-generation sequencing) is also preferred.
Interested individuals who meet the above criteria may apply by sending CV to:
Anthony J. Aldave, M.D.
Associate Professor of Ophthalmology
Director, Cornea Genetics Laboratory
Director, Cornea Service
Director, Cornea and Refractive Surgery Fellowship
The Jules Stein Eye Institute
100 Stein Plaza, UCLA
Los Angeles, CA 90095-7003
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