Research Associate/Senior Research Associate Protein Chemistry
Astellas Pharmaceuticals - Santa Monica, CA

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At Agensys, we're changing tomorrow by moving oncology forward. We've developed a pipeline of novel therapeutic fully human monoclonal antibodies (MAbs) to treat solid tumors based on our own proprietary targets. We have discovered and validated a portfolio of clinically relevant targets in 14 different cancer types. Our pipeline includes therapeutic MAbs to multiple cancer indications that are at different stages of clinical and pre-clinical development.

Our parent company, Astellas Pharma US helps us shine. Together we are the bright spot in the pharmaceutical industry -- not just because of what we do, but in the way we do it. If you are looking for a company where you can change a life, make a dream come true, and light the way for a better tomorrow, this is the place for you.

Astellas, and our Agensys subsidiary, offer a different kind of work culture. A high standard of ethics is mandatory. Quality is our pledge. Diversity is valued. Individual initiative is rewarded. Astellas offers an environment where our employees can make a real difference. To continue to change tomorrow, Astellas/Agensys must recruit the best and brightest in the industry.

Come, shine with us!

Purpose & Scope:
At Astellas we are looking for a research associate with minimum two years of industrial experience in protein expression, purification and characterization.

Essential Job Responsibilities:

The postion will be responsible for preparation and characterization of protein reagents in R &D. This is a position with great responsibility working on multiple projects at all times. S/he will be responsible for timely delivery of the protein reagents as well as for their quality and quantity.

Quantitative Dimensions:
She/he will have to produce and characterize protein reagents for multiple functions within R&D and PD. Therefore s/he will have to efficiently communicate horizontally and vertically with all participating departments and functions.

Organizational Context:
This position will report to the Group Leader Protein Science interacting with downstream and upstream functionalities of R&D mainly molecular biology, antibody production,assay development and product development.

Hands on experience in variety of expression systems preferably 293T, CHO and E. coli small (1L) and medium scale up to 50L as well as using automated protein purification systems (AKTAXpress, AKTA Avant and/or others) in variety of modes (affinity, ion exchange, HIC, chromatofocusing, multimode, IEF). S/he should be able to follow up with the analytical characterization of purified proteins using analytical protein assays, SDS PAGE, HPLC, CE, size exclusion chromatography, differential scanning calorimetry, multiangle light scattering, mass spectrometry and others.Versatile computer skills and capability to quickly comprehend and operate complex scientific instruments and software are quite essential.

Important is the capability to creatively troubleshoot problems and being comfortable with fast pacing team environment where everyone takes personal responsibility for his/her quality of work and its delivery on time. S/he should be detail oriented, dependable and be able to communicate with other in positive and constructive way.



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