Located in Boston, Dana Farber Cancer Institute brings together world-renowned clinicians, innovative researchers, and dedicated professionals as allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow’s physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
The Polyak Laboratory is looking for a Research Fellow for a recently funded multi-investigator/laboratory epigentics project, entitled "Epigenetic dependencies in human cancer."
This proposal aims to (1) identify epigenetic regulators of survival in a lineage or oncogene specific manner via systematic shRNA knockdown in cell panels (~20 from each) of prostate, TNBC, Rhabdoid, Neuroblastoma and CRC (cell panels not overlapping with NVS CLE panel), (2) to characterise the target(s) of these regulators in sensitive and resistant backgrounds by e.g. ChIPseq (3) to reproduce any “synthetic lethal” phenotypes by co-knockdown in a wild-type background and (4) to generate and characterise a cell line panel with somatic knock out (or in of mutant) identified in (1) and (2) above.
PhD, MD, or combination. Looking for education/background in Molecular Biology, Genetics and Breast Cancer.
Full-time Regular Employee / Monthly Paid.
Dana-Farber Cancer Institute is an Affirmation Action/Equal Opportunity Employer, committed to diversity and inclusion in our workforce.
Dana-Farber Cancer Institute - 16 months ago