Research Scientist
California Institute for Biomedical Research - La Jolla, CA

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Calibr is seeking a highly motivated individual for a position within Pharmacokinetics and Drug Metabolism group (La Jolla, CA). The individual will focus on providing in vitro and bioanalytical support for discovery and development of novel drug candidates for the treatment of various diseases with high unmet medical need. The position requires good bioanalytical skills and laboratory experience, with an emphasis on in vitro experiments and use of liquid chromatography, mass spectrometry, and automation. This role will perform experiments, organize, and analyze results with minimal supervision, as well as communicate and present in team meetings. This role will be expected to follow established experimental protocols as well as develop and implement new assays as required.

Qualifications:

  • Ph.D./MS/BS in pharmacokinetics, analytical chemistry, or a related field required with 0-2 years (PhD), 3-5 years (MS), or 8-10 years (BS) of industry experience that is directly related to DMPK and bioanalysis
  • Proven general knowledge and formal training (i.e., course work) in pharmacokinetics
  • Knowledge and hands-on experience in non-compartmental pharmacokinetic analysis using WinNonlin/Phoenix software
  • The candidate should have proven laboratory experience in quantitation of small molecules in biological matrices using LC-MS/MS
  • In addition, the successful candidate should have a proven ability to work independently and troubleshoot effectively
  • Further, the candidate must be highly motivated, organized, proactive, and capable of multi-tasking
  • He/she must possess excellent verbal, written, interpersonal and collaborative communication skills

Specific requirements:

  • Developing small molecule LC-MS/MS methods and quantifying in various biological matrices (plasma, brain, whole-blood, etc) in support of exploratory PK and other in vivo efficacy studies
  • Organizing analytical run data and analyzing results
  • Performing non-compartmental analysis and reporting results to project teams
  • Prefer experience in protein MS/MS for pharmacokinetic analysis of antibodies and protein therapeutics
  • Prefer experience in performing in vitro ADME assays including solubility, Cyp P450, metabolic stability and metabolite ID
  • Maintaining one LC-MS/MS system (AbSciex) and independently troubleshooting when needed
  • Participating in group project meetings
  • Maintaining proper documentation, such as laboratory notebooks and/or computer files
  • Maintaining excellent written and oral communication with supervisors, peers, and team members at all times

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