Senior Associate Scientist
Sanford-Burnham Medical Research Institute - Orlando, FL

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A Biology/HTS assay development Senior Associate Scientist position is available to join the Conrad Prebys Center for Chemical Genomics (CPCCG) and contribute toward our chemical biology and drug discovery efforts at Sanford-Burnham Medical Research Institute in Lake Nona. The position offers a challenging frontline role in assay conceptualization, design and optimization to support uHTS assay development projects.

Under general direction, the Senior Associate Scientist will support hit validation and hit-to lead pharmacology efforts for advanced projects and work collaboratively through dedicated laboratory efforts within a team of other scientists including biologists, HTS specialists and medicinal chemists to rapidly and creatively design, develop and optimize diverse cell-based and biochemical assays for uHTS and early-stage drug discovery.

Will plan and manage all aspects of assigned research projects, independently analyze results and formulate conclusions, independently identify and develop solutions to technical problems, and perform other related duties and tasks as required or assigned.

Required Skills

Required Experience

Requires a bachelors degree in a biological science, chemistry, physics or a related field and a minimum of 5 years (and typically up to 10 years) of directly related experience, or an equivalent combination of education, training and experience from which comparable knowledge, skills and abilities have been attained. Candidates with a masters degree, a minimum of 2 years (and typically up to 5 years) are required. Relevant, hands-on laboratory experience in a drug discovery environment is strongly desired.

Requires previous demonstrated experience with multiwell plate preparation and liquid handling instruments. Working knowledge of the principles of protein chemistry, enzymology and cell biology and high content imaging is highly desirable. Expertise in implementing and running HTS assays, cell culture and molecular biology techniques is highly beneficial.

The successful candidate must have a demonstrated mastery of the variety and breadth of modern HTS assay development technologies and approaches. The Associate Scientist must have the ability to work equally well independently or as part of a team, and effectively handle multiple projects of varied degrees of difficulty and duration. The ability to exercise independent judgment regarding the interpretation and optimization of experimental data and to thrive in a rapidly changing, deadline-driven environment is essential. Concise analytical reasoning coupled to a practical, pragmatic yet flexible and creative troubleshooting approach is highly beneficial.

Requires a professional demeanor, time management, and organizational skills, and excellent verbal/written communication and interpersonal skills. Must have professional proficiency in Microsoft Office and the ability to learn department-specific computer systems as needed.

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