Senior Scientist, PD/Biomarker
Merck 1,080 reviews - Billerica, MA

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PURPOSE OF THE ROLE

1. Lead a team of technicians aiming to develop,
maintain, and provide expertise in rodent PK/PD biomarker studies
and conceptual inflammation models.

2. Establish PK/PD and conceptual inflammation models
querying disease mechanisms, clinical readouts, and complex
biomarkers translatable to patients. Build database of reference
treatments in disease models.

3. Proficient in technologies useful in biomarker
determination including flow cytometry, QPCR, luminex, ELISA
etc.

4. Propose, execute, and present results of innovative
experiments. Provide written and oral presentations of results to
members of the immunology group and project teams. Provide
decision-enabling pharmacological data supporting the advancement
of discovery projects from DPLO to DP1.

5. Contribute to the recognition of Merck Serono as a
global player in the field of Immunology by scientific
publications.

6. Serve on internal discovery project teams as team
member. Support in-licensing efforts and contribute to Due
Diligence upon request.

KEY TASKS & RESPONSIBILITIES

Support specific projects by providing expertise in in vivo
pharmacology of PK/PD and conceptual models of
inflammation.

Validate pathways and biomarkers in conceptual models with
a strong focus on markers translatable to the clinical
setting.

Conduct original research contributing to the recognition
of Merck Serono in the scientific community. Publish scientific
work in peer-reviewed journals.

Design, execute, analyze, and present results of innovative
experiments

Evaluate and implement innovative technologies for solving
scientific questions and maximizing the gain of information
from pharmacological models.

Direct management of 2-3 associate scientists or research
associates. Develop and recommend objectives of direct
reports.

Write animal protocols and ensure adherence to animal
welfare guidelines.

Ensure adherence to quality standards as well as proper
documentation of experimental results.

Build and maintain strong network of academic experts.

Propose new targets / Evaluate external opportunities.
Detect, recognize and communicate trends/events outside the
company which will alter the direction of a therapeutic
area/technology.

Have a thorough understanding of the strategic importance
of Research projects and their direct impact on the company’s
success. Have a good overview of the R&D pipeline.

Be responsible for implementing and maintaining a
state-of-the-art laboratory environment.

MAIN INTERFACES

INTERNALLY

:

Intra-Therapeutic Area (TA) interactions: Exploratory
Immunology, Cellular Immunology, and Clinical Immunology.

Inter TA interactions: Project teams, LDT, Toxicology,
DMPK, NBE-Tech, NCE-Tech etc.

Clinical development and Business Development.

EXTERNALLY

:

CRO

Academic collaborators and network of scientific
experts

Qualifications

EDUCATION & LANGUAGES

Degree: PhD or MD/PhD in immunology with considerable basic
research experience.

Excellent knowledge of written and spoken English.

PROFESSIONAL SKILLS & EXPERIENCE

Thorough understanding of innate and adaptive immunology
with focus on adaptive or innate immunology. Hands-on experience
in running conceptual models of inflammation relevant to T and B
cell activation and innate immune mechanisms.

Strong technical expertise and hands-on experience in in
vitro and in vivo immunological methods as well as flow
cytometry, molecular biology, and biochemical techniques.

Experience with inflammation-induced kidney damage a
plus.

Capable of teaching relevant techniques to research
associates.

3-5 years of postdoctoral experience in academia or
pharmaceutical setting.

Excellent academic network

Track record of scientific publications

Track record of establishing new immunological models and
methods

PERSONAL SKILLS & COMPETENCIES

Innovative thinking approach, excellent communication
skills.

Experience in
managing research associates or students a plus

About this company
1,080 reviews
Merck makes medicines for a number of maladies, from stuffy noses and asthma to hypertension and arthritis. The pharmaceutical giant's...