Sr Immunohisto-Biologics Distribution
AbbVie - Worcester, MA

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130000021I

Description

AbbVie (NYSE: ABBV) is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott. AbbVie combines the focus and passion of a leading-edge biotech with the expertise and capabilities of a long-established pharmaceutical leader to develop and market advanced therapies that address some of the world

Job description

:

Accomplished Immunohistochemist who will make substantial contributions to the conception, execution and communication of novel multi-disciplinary research strategies in Immunology drug discovery programs in a highly collaborative environment. The successful candidate will w

ork in a group providing research in target validation, target distribution, animal model development, and in performing molecular and toxicologic pathology in pharmacology and exploratory safety studies.

A primary responsibility of the successful candidate will be to work closely with Biologics to understand how physical and targeting properties of Biologic molecules alters their distribution, penetration and retention in tissues.

Using histology and immunohistochemistry techniques, the candidate will characterize and quantify local expression and in vivo distribution of Biologics to guide understanding of targeted approaches to Drug Discovery, generating high-quality, stage-gate appropriate data packages supporting compound transitions. The successful candidate will also design in vivo studies to support histologic endpoints and evaluate utility of additional novel antibody detection techniques tissue mass spec imaging to in vivo imaging technologies.

In addition, he/she will develop new techniques and technologies to increase confidence on the translatability of findings to human disease. It is expected that the candidate will utilize his/her expertise to generate external collaborations with key opinion leaders to identify opportunities for novel technologies

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Qualifications

Qualifications

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PhD or equivalent in Immunology or related field with significant research experience in histology and immunohistochemistry techniques as demonstrated by track record of publications and scientific accomplishments. Strong scientific expertise in Immunohistochemistry/In situ Hybridization and other histologic techniques is required. Detailed knowledge of state-of-the-art tools and approaches to imaging target expression is required. Experience in both biologic and small molecule therapeutic research a plus. Proven ability to lead in a highly collaborative environment. Highly developed leadership and communication skills and keen ability to engage external scientific leaders in collaborative research.

Education Requirements

BS & 14-16 years of experience; MS & 12-14 years of experience; PhD and 6-10 years of experience. Required to ensure that incumbent has necessary theoretical and practical knowledge to do the job.

Significant Work Activities and Conditions

Continuous standing for prolonged periods ( more than 2 consecutive houres in an 8 hour day), Routine work with chemicals

Job Classification

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Experienced

Job

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RESEARCH AND DEVELOPMENT

Primary Location

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USA-Massachusetts-Worcester

Organization

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GPRD-Pharma R&D

Schedule

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Full-time

Shift

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Day

Travel

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Yes, 10 % of the Time

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