Vertex Pharmaceuticals is focused on solutions for real medical need that makes a difference in people's lives. They attract smart motivated people and give them the resources they need to succeed.
A requirement of the job is to successfully sell your project among all the competing proposals from other smart people in the company. Vertex is focused on leaders being able to develop compelling arguments, persuade Vertexians on the value proposition, and collaborate with others to achieve goals as opposed to have the top management just dictate what projects will be active and how many resources they assign to the work.
This fostering of value and data driven decisions via a competition is energizing for some but can be frustrating for people used to big Pharma hierarchical decision making. This also makes hiring team members from big Pharma a bit risky since they may expect others to run interference for them.
Overall, a great place to work if you are ambitious and focused on the value you are creating in pursuit of products that help with serious unmet medical needs.