High-paying nursing jobs in Sioux Falls

Nursing is caring for patients and managing healthcare. Nurses provide essential support by monitoring patient conditions and administering treatments. They need empathy, attention to detail, and strong communication skills to deliver quality care.


The 344 nursing jobs listed below pay well, with salaries between $51,229 and $125,161 per year. Registered Nurse, Licensed Practical Nurse and Registered Practical Nurse are among the most popular high-paying roles in Sioux Falls, SD.

Job title

Updated Oct 28, 2026
Job title
Sioux Falls, SD
South Dakota
Job openings (Sioux Falls)

Nurse Practitioner

Sioux Falls

$83.41 per hour

South Dakota

$117 per hour

Registered Nurse - Dialysis

Sioux Falls

$2,290 per week

South Dakota

$2,212 per week

Travel Nurse

Sioux Falls

$2,223 per week

South Dakota

$2,164 per week

Registered Nurse - Medical/Surgical

Sioux Falls

$2,200 per week

South Dakota

$2,234 per week

Psychiatric Nurse

Sioux Falls

$2,136 per week

South Dakota

$2,091 per week

Registered Nurse

Sioux Falls

$38.32 per hour

South Dakota

$40.07 per hour

Licensed Practical Nurse

Sioux Falls

$1,501 per week

South Dakota

$1,687 per week

Clinical Lead Nurse

Sioux Falls

$33.32 per hour

South Dakota

$33.50 per hour

Registered Practical Nurse

Sioux Falls

$30.79 per hour

South Dakota

$31.30 per hour

Nursing Assistant

Sioux Falls

$22.68 per hour

South Dakota

$23.05 per hour

Job descriptions below are for educational purposes. Please refer to the employer's job description for complete details.