High-paying nursing jobs in Sioux Falls
Nursing is caring for patients and managing healthcare. Nurses provide essential support by monitoring patient conditions and administering treatments. They need empathy, attention to detail, and strong communication skills to deliver quality care.
The 360 nursing jobs listed below pay well, with salaries between $50,965 and $121,976 per year. Registered Nurse, Licensed Practical Nurse and Nursing Assistant are among the most popular high-paying roles in Sioux Falls, SD.
Job title
Updated Sep 10, 2026
Job title
Sioux Falls, SD
South Dakota
Job openings (Sioux Falls)
Nurse Practitioner
Sioux Falls
$86.75
per hour
South Dakota
$116
per hour
Travel Nurse
Sioux Falls
$2,231
per week
South Dakota
$2,167
per week
Registered Nurse - Medical/Surgical
Sioux Falls
$2,162
per week
South Dakota
$2,217
per week
Psychiatric Nurse
Sioux Falls
$2,124
per week
South Dakota
$2,094
per week
Registered Nurse
Sioux Falls
$38.21
per hour
South Dakota
$39.83
per hour
Registered Nurse - Pediatrics
Sioux Falls
$36.23
per hour
South Dakota
$56.87
per hour
Clinical Lead Nurse
Sioux Falls
$33.06
per hour
South Dakota
$33.51
per hour
Registered Practical Nurse
Sioux Falls
$30.69
per hour
South Dakota
$31.27
per hour
Licensed Practical Nurse
Sioux Falls
$30.35
per hour
South Dakota
$33.51
per hour
Nursing Assistant
Sioux Falls
$22.56
per hour
South Dakota
$22.94
per hour
Job descriptions below are for educational purposes. Please refer to the employer's job description for complete details.
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Nurse Practitioner
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Please refer to the employers job description for complete details.
Nurse Practitioners diagnose patients, prescribe medications, and collaborate with healthcare teams. Requires advanced clinical skills, autonomy in practice, and a valid NP license.
Nurse Practitioner jobs take 100 days on average from job posting to starting date. Currently, 10% of job openings offer remote or hybrid positions and 22% of job openings are part-time roles.
See 21 jobsAverage pay
Sioux Falls
$86.75 per hourSouth Dakota
$116 per hourSkills
- Nursing
- Primary care
- Patient care
- EMR systems
- Communication skills
-
Travel Nurse
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Please refer to the employers job description for complete details.
Travel Nurses provide healthcare services in various locations, adapt to new environments, and ensure patient care standards. Nursing credential, flexibility, and strong clinical skills are crucial.
Travel Nurse jobs take 51 days on average from job posting to starting date. Currently, 3% of job openings are part-time roles.
See 19 jobsAverage pay
Sioux Falls
$2,231 per weekSouth Dakota
$2,167 per weekSkills
- Nursing
- Medication administration
- Patient care
- Acute care
- Care plans
-
Registered Nurse - Medical/Surgical
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Please refer to the employers job description for complete details.
Registered nurses in medical-surgical care provide patient care, monitor vitals and administer treatments. Expertise in nursing procedures, patient assessment, and emergency response is essential in this role.
See 23 jobsAverage pay
Sioux Falls
$2,162 per weekSouth Dakota
$2,217 per week -
Psychiatric Nurse
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Please refer to the employers job description for complete details.
Psychiatric nurses assess mental health needs, administer medications and provide therapeutic interventions. Proficiency in psychiatric nursing, empathy and crisis intervention skills are essential.
Psychiatric Nurse jobs take 40 days on average from job posting to starting date. Currently, 24% of job openings are part-time roles.
See 11 jobsAverage pay
Sioux Falls
$2,124 per weekSouth Dakota
$2,094 per weekSkills
- Behavioral health
- Psychiatric care
- Psychiatry
- Computer skills
- Acute care
-
Registered Nurse
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Please refer to the employers job description for complete details.
Registered Nurses provide patient care, administer treatments, and coordinate with healthcare teams. Nursing licensure, clinical expertise, and strong communication skills are essential.
Registered Nurse jobs take 59 days on average from job posting to starting date. Currently, 23% of job openings are part-time roles.
See 90 jobsAverage pay
Sioux Falls
$38.21 per hourSouth Dakota
$39.83 per hourSkills
- Nursing
- Patient care
- Physiology knowledge
- Medical documentation
- Hindi
-
Registered Nurse - Pediatrics
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Please refer to the employers job description for complete details.
Pediatric RNs administer care to children, educate families and coordinate with healthcare teams. Specialized pediatric nursing skills, empathy and strong communication abilities are essential.
Registered Nurse - Pediatrics jobs take 41 days on average from job posting to starting date. Currently, 39% of job openings are part-time roles.
See 8 jobsAverage pay
Sioux Falls
$36.23 per hourSouth Dakota
$56.87 per hourSkills
- Pediatrics
- Home & community care experience
- English
- Computer skills
- Acute care
-
Clinical Lead Nurse
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Please refer to the employers job description for complete details.
Clinical lead nurses guide nursing teams, ensure care standards and optimize workflows. Candidates benefit from strong clinical expertise, leadership capabilities and excellent communication skills.
Clinical Lead Nurse jobs take 44 days on average from job posting to starting date. Currently, 13% of job openings are part-time roles.
See 25 jobsAverage pay
Sioux Falls
$33.06 per hourSouth Dakota
$33.51 per hourSkills
- Clinic experience
- Leadership
- Organizational skills
- Computer skills
- Acute care
-
Registered Practical Nurse
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Please refer to the employers job description for complete details.
Registered practical nurses provide patient care, administer medications and monitor health conditions. Key qualifications for this role include nursing licensure, clinical skills and compassion.
Registered Practical Nurse jobs take 67 days on average from job posting to starting date. Currently, 48% of job openings are part-time roles.
See 44 jobsAverage pay
Sioux Falls
$30.69 per hourSouth Dakota
$31.27 per hourSkills
- Long term care experience
- Vital signs
- Geriatrics
- Patient monitoring
- English
-
Licensed Practical Nurse
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Please refer to the employers job description for complete details.
Licensed Practical Nurses provide patient care, monitor vital signs, and assist doctors. Nursing license, proficiency in medical equipment, and strong interpersonal skills are essential.
Licensed Practical Nurse jobs take 55 days on average from job posting to starting date. Currently, 32% of job openings are part-time roles.
See 70 jobsAverage pay
Sioux Falls
$30.35 per hourSouth Dakota
$33.51 per hourSkills
- Nursing
- Medication administration
- Patient care
- Care plans
- Patient monitoring
-
Nursing Assistant
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Please refer to the employers job description for complete details.
Nursing Assistants assist with patient care, monitor vital signs, and support nursing staff. Compassionate demeanor, basic knowledge of medical procedures, and physical stamina are essential attributes.
Nursing Assistant jobs take 56 days on average from job posting to starting date. Currently, 41% of job openings are part-time roles.
See 49 jobsAverage pay
Sioux Falls
$22.56 per hourSouth Dakota
$22.94 per hourSkills
- Nursing
- Patient care
- Medical documentation
- Physiology knowledge
- Medical records