High-paying nursing jobs in Sioux Falls
Nursing is caring for patients and managing healthcare. Nurses provide essential support by monitoring patient conditions and administering treatments. They need empathy, attention to detail, and strong communication skills to deliver quality care.
The 344 nursing jobs listed below pay well, with salaries between $51,229 and $125,161 per year. Registered Nurse, Licensed Practical Nurse and Registered Practical Nurse are among the most popular high-paying roles in Sioux Falls, SD.
Job title
Updated Oct 28, 2026Nurse Practitioner
Sioux Falls
South Dakota
Registered Nurse - Dialysis
Sioux Falls
South Dakota
Travel Nurse
Sioux Falls
South Dakota
Registered Nurse - Medical/Surgical
Sioux Falls
South Dakota
Psychiatric Nurse
Sioux Falls
South Dakota
Registered Nurse
Sioux Falls
South Dakota
Licensed Practical Nurse
Sioux Falls
South Dakota
Clinical Lead Nurse
Sioux Falls
South Dakota
Registered Practical Nurse
Sioux Falls
South Dakota
Nursing Assistant
Sioux Falls
South Dakota
Job descriptions below are for educational purposes. Please refer to the employer's job description for complete details.
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Nurse Practitioner
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Nurse Practitioners diagnose patients, prescribe medications, and collaborate with healthcare teams. Requires advanced clinical skills, autonomy in practice, and a valid NP license.
Nurse Practitioner jobs take 99 days on average from job posting to starting date. Currently, 11% of job openings offer remote or hybrid positions and 22% of job openings are part-time roles.
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Sioux Falls
$83.41 per hourSouth Dakota
$117 per hour -
Registered Nurse - Dialysis
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Registered dialysis nurses manage dialysis treatments, monitor patients and educate families. RN licensure, dialysis experience and strong communication skills are essential in this role.
Registered Nurse - Dialysis jobs take 35 days on average from job posting to starting date. Currently, 12% of job openings are part-time roles.
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Sioux Falls
$2,290 per weekSouth Dakota
$2,212 per weekSkills
- Nursing
- Patient monitoring
- Hindi
- Data analysis skills
- Patient observation
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Travel Nurse
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Travel Nurses provide healthcare services in various locations, adapt to new environments, and ensure patient care standards. Nursing credential, flexibility, and strong clinical skills are crucial.
Travel Nurse jobs take 42 days on average from job posting to starting date. Currently, 2% of job openings are part-time roles.
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Sioux Falls
$2,223 per weekSouth Dakota
$2,164 per week -
Registered Nurse - Medical/Surgical
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Registered nurses in medical-surgical care provide patient care, monitor vitals and administer treatments. Expertise in nursing procedures, patient assessment, and emergency response is essential in this role.
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Sioux Falls
$2,200 per weekSouth Dakota
$2,234 per week -
Psychiatric Nurse
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Psychiatric nurses assess mental health needs, administer medications and provide therapeutic interventions. Proficiency in psychiatric nursing, empathy and crisis intervention skills are essential.
Psychiatric Nurse jobs take 45 days on average from job posting to starting date. Currently, 25% of job openings are part-time roles.
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Sioux Falls
$2,136 per weekSouth Dakota
$2,091 per week -
Registered Nurse
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Registered Nurses provide patient care, administer treatments, and coordinate with healthcare teams. Nursing licensure, clinical expertise, and strong communication skills are essential.
Registered Nurse jobs take 67 days on average from job posting to starting date. Currently, 24% of job openings are part-time roles.
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Sioux Falls
$38.32 per hourSouth Dakota
$40.07 per hourSkills
- Nursing
- Patient care
- Physiology knowledge
- Medical documentation
- Hindi
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Licensed Practical Nurse
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Licensed Practical Nurses provide patient care, monitor vital signs, and assist doctors. Nursing license, proficiency in medical equipment, and strong interpersonal skills are essential.
Licensed Practical Nurse jobs take 57 days on average from job posting to starting date. Currently, 32% of job openings are part-time roles.
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Sioux Falls
$1,501 per weekSouth Dakota
$1,687 per week -
Clinical Lead Nurse
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Clinical lead nurses guide nursing teams, ensure care standards and optimize workflows. Candidates benefit from strong clinical expertise, leadership capabilities and excellent communication skills.
Clinical Lead Nurse jobs take 55 days on average from job posting to starting date. Currently, 13% of job openings are part-time roles.
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Sioux Falls
$33.32 per hourSouth Dakota
$33.50 per hour -
Registered Practical Nurse
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Registered practical nurses provide patient care, administer medications and monitor health conditions. Key qualifications for this role include nursing licensure, clinical skills and compassion.
Registered Practical Nurse jobs take 68 days on average from job posting to starting date. Currently, 44% of job openings are part-time roles.
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Sioux Falls
$30.79 per hourSouth Dakota
$31.30 per hour -
Nursing Assistant
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Please refer to the employers job description for complete details.
Nursing Assistants assist with patient care, monitor vital signs, and support nursing staff. Compassionate demeanor, basic knowledge of medical procedures, and physical stamina are essential attributes.
Nursing Assistant jobs take 59 days on average from job posting to starting date. Currently, 41% of job openings are part-time roles.
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Sioux Falls
$22.68 per hourSouth Dakota
$23.05 per hourSkills
- Nursing
- Patient care
- Medical documentation
- Physiology knowledge
- Medical records