Nurse practitioner salary in Durham, NC

The average salary for a Nurse Practitioner is $143,980 per year in Durham, NC. This figure is based on 38 salaries taken from job postings on Indeed in the past 36 months, last updated on July 21, 2026.

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Nurse Practitioner salaries in Durham, NC typically range between a low of $108,740 and a high of $190,639 per year, depending on experience and the hiring company.

Some of the highest-paying cities for Nurse Practitioner in Durham, NC include Fayetteville, NC at $127,904 per year, Raleigh, NC at $126,219 per year, and Greensboro, NC at $126,065 per year.

Based on recent job postings on Indeed, some of the top-paying companies for Nurse Practitioner in Durham, NC include Abacus Staffing ($166,400 per year) and Cross Country ($161,200 per year).

Compensation can vary based on the specific niche and level of responsibility within the field. Here is how the average Nurse Practitioner salary in Durham, NC compares to related positions:

• Lead Nurse Practitioner: Average $141,196 per year
• Nurse Practitioner II: Average $65.71 per hour
• Senior Nurse Practitioner: Average $117,967 per year