Nurse practitioner salary in Durham, NC

The average salary for a Nurse Practitioner is $143,513 per year in Durham, NC. This figure is based on 40 salaries taken from job postings on Indeed in the past 36 months, last updated on August 14, 2026.

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Nurse Practitioner salaries in Durham, NC typically range between a low of $108,558 and a high of $189,723 per year, depending on experience and the hiring company.

Some of the highest-paying cities for Nurse Practitioner in Durham, NC include Fayetteville, NC at $128,221 per year, Greensboro, NC at $126,401 per year, and Raleigh, NC at $126,279 per year.

Based on recent job postings on Indeed, some of the top-paying companies for Nurse Practitioner in Durham, NC include Abacus Staffing ($166,400 per year) and Cross Country ($161,200 per year).

Compensation can vary based on the specific niche and level of responsibility within the field. Here is how the average Nurse Practitioner salary in Durham, NC compares to related positions:

• Lead Nurse Practitioner: Average $141,523 per year
• Nurse Practitioner II: Average $66.04 per hour
• Senior Nurse Practitioner: Average $118,836 per year