Nurse practitioner salary in St. Louis, MO

The average salary for a Nurse Practitioner is $124,366 per year in St. Louis, MO. This figure is based on 222 salaries taken from job postings on Indeed in the past 36 months, last updated on August 12, 2026.

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Nurse Practitioner salaries in St. Louis, MO typically range between a low of $95,096 and a high of $162,646 per year, depending on experience and the hiring company.

Some of the highest-paying cities for Nurse Practitioner in St. Louis, MO include Rolla, MO at $250,730 per year, Joplin, MO at $210,593 per year, and Saint Joseph, MO at $166,220 per year.

Based on recent job postings on Indeed, some of the top-paying companies for Nurse Practitioner in St. Louis, MO include Veteran Medical Group ($520,000 per year) and Capitol Bridge ($353,600 per year).

Compensation can vary based on the specific niche and level of responsibility within the field. Here is how the average Nurse Practitioner salary in St. Louis, MO compares to related positions:

• Lead Nurse Practitioner: Average $143,043 per year
• Nurse Practitioner II: Average $67.03 per hour
• Senior Nurse Practitioner: Average $120,621 per year