High-paying nursing jobs in Irvine
Nursing is caring for patients and managing healthcare. Nurses provide essential support by monitoring patient conditions and administering treatments. They need empathy, attention to detail, and strong communication skills to deliver quality care.
The 966 nursing jobs listed below pay well, with salaries between $24.03 and $72.37 per hour. Licensed Vocational Nurse, Nursing Assistant and Registered Nurse are among the most popular high-paying roles in Irvine, CA.
Job title
Updated Oct 05, 2026Nurse Practitioner
Irvine
California
Senior Clinical Nurse
Irvine
California
Clinical Nurse
Irvine
California
Nurse Manager
Irvine
California
Registered Nurse - Home Health
Irvine
California
Registered Nurse
Irvine
California
Licensed Vocational Nurse
Irvine
California
Nursing Assistant
Irvine
California
Job descriptions below are for educational purposes. Please refer to the employer's job description for complete details.
-
Nurse Practitioner
Review job description
Please refer to the employers job description for complete details.
Nurse Practitioners diagnose patients, prescribe medications, and collaborate with healthcare teams. Requires advanced clinical skills, autonomy in practice, and a valid NP license.
The top companies hiring Nurse Practitioner in Irvine, CA are City of Hope (3 jobs), Optum (1 job), and UC Irvine Health (1 job).
Nurse Practitioner jobs take 101 days on average from job posting to starting date. Currently, 11% of job openings offer remote or hybrid positions and 21% of job openings are part-time roles.
See 99 jobsAverage pay
Irvine
$84.53 per hourCalifornia
$107 per hourSkills
- Nursing
- Primary care
- Patient care
- EMR systems
- Communication skills
-
Senior Clinical Nurse
Review job description
Please refer to the employers job description for complete details.
Senior clinical nurses plan patient care strategies, supervise nursing staff and manage complex cases. Advanced clinical expertise, excellent leadership skills and in-depth knowledge of patient care are essential in this role.
The top companies hiring Senior Clinical Nurse in Irvine, CA are City of Hope (7 jobs), UC Irvine Health (4 jobs), and Hoag Health System (1 job).
Senior Clinical Nurse jobs take 7 days on average from job posting to starting date. Currently, 26% of job openings are part-time roles.
See 24 jobsAverage pay
Irvine
$72.37 per hourCalifornia
$86.40 per hourSkills
- Medical-surgical
- ICU experience
- Surgery
- Computer skills
- Time management
-
Clinical Nurse
Review job description
Please refer to the employers job description for complete details.
Clinical nurses administer treatments, assess patient needs and collaborate with healthcare teams. Proficiency in clinical procedures, strong assessment skills and compassion are essential.
Clinical Nurse jobs take 43 days on average from job posting to starting date. Currently, 15% of job openings are part-time roles.
See 5 jobsAverage pay
Irvine
$65.53 per hourCalifornia
$44.59 per hour -
Nurse Manager
Review job description
Please refer to the employers job description for complete details.
Nurse Managers supervise nursing staff, develop care standards, and manage department budgets. Key skills include leadership expertise, clinical knowledge, and financial management.
The top companies hiring Nurse Manager in Irvine, CA are City of Hope (2 jobs), Green Key Resources (1 job), and UC Irvine Health (1 job).
Nurse Manager jobs take 44 days on average from job posting to starting date. Currently, 3% of job openings are part-time roles.
See 20 jobsAverage pay
Irvine
$132,085 per yearCalifornia
$145,878 per yearSkills
- Nursing
- Management
- Supervising experience
- Patient care
- Leadership
-
Registered Nurse - Home Health
Review job description
Please refer to the employers job description for complete details.
Registered Nurses - Home Health provide patient care, monitor health conditions, and liaise with healthcare teams. Nursing degree, licensure, and ability to work independently ensure quality patient support.
The top companies hiring Registered Nurse - Home Health in Irvine, CA are Alliance Health Services (2 jobs), Acacia Health (2 jobs), and Providence at Home with Compassus (2 jobs).
Registered Nurse - Home Health jobs take 61 days on average from job posting to starting date. Currently, 28% of job openings are part-time roles.
See 79 jobsAverage pay
Irvine
$58.50 per hourCalifornia
$67.62 per hourSkills
- Nursing
- Patient care
- Medication administration
- Home health
- Care plans
-
Registered Nurse
Review job description
Please refer to the employers job description for complete details.
Registered Nurses provide patient care, administer treatments, and coordinate with healthcare teams. Nursing licensure, clinical expertise, and strong communication skills are essential.
The top companies hiring Registered Nurse in Irvine, CA are Kaiser Permanente (9 jobs), VITAS Healthcare (1 job), and Synergy Staffing LLC (1 job).
Registered Nurse jobs take 59 days on average from job posting to starting date. Currently, 23% of job openings are part-time roles.
See 239 jobsAverage pay
Irvine
$51.52 per hourCalifornia
$55.75 per hourSkills
- Nursing
- Patient care
- Physiology knowledge
- Medical documentation
- Hindi
-
Licensed Vocational Nurse
Review job description
Please refer to the employers job description for complete details.
Licensed Vocational Nurses provide patient care, administer medications, and document treatments. Clinical knowledge, empathy, and attention to procedural details are critical for ensuring patient well-being.
The top companies hiring Licensed Vocational Nurse in Irvine, CA are Newport Hospice (2 jobs), UC Irvine Health (1 job), and BrightStar Care (1 job).
Licensed Vocational Nurse jobs take 52 days on average from job posting to starting date. Currently, 29% of job openings are part-time roles.
See 252 jobsAverage pay
Irvine
$33.12 per hourCalifornia
$36.33 per hourSkills
- Nursing
- Medication administration
- Patient care
- Care plans
- Long term care experience
-
Nursing Assistant
Review job description
Please refer to the employers job description for complete details.
Nursing Assistants assist with patient care, monitor vital signs, and support nursing staff. Compassionate demeanor, basic knowledge of medical procedures, and physical stamina are essential attributes.
The top companies hiring Nursing Assistant in Irvine, CA are UC Irvine Health (4 jobs), HumanGood (3 jobs), and 2nd Family (2 jobs).
Nursing Assistant jobs take 55 days on average from job posting to starting date. Currently, 40% of job openings are part-time roles.
See 248 jobsAverage pay
Irvine
$24.03 per hourCalifornia
$23.82 per hourSkills
- Nursing
- Patient care
- Medical documentation
- Physiology knowledge
- Medical records