High-paying nursing jobs in Irvine
Nursing is caring for patients and managing healthcare. Nurses provide essential support by monitoring patient conditions and administering treatments. They need empathy, attention to detail, and strong communication skills to deliver quality care.
The 826 nursing jobs listed below pay well, with salaries between $78,273 and $300,967 per year. Licensed Vocational Nurse, Registered Nurse and Nurse Practitioner are among the most popular high-paying roles in Irvine, CA.
Job title
Updated Aug 20, 2026
Job title
Irvine, CA
California
Job openings (Irvine)
Nurse Practitioner
Irvine
$82.72
per hour
California
$107
per hour
Senior Clinical Nurse
Irvine
$72.37
per hour
California
$85.67
per hour
Nurse Manager
Irvine
$138,527
per year
California
$146,116
per year
Registered Nurse Case Manager
Irvine
$2,624
per week
California
$2,601
per week
Registered Nurse - Home Health
Irvine
$2,601
per week
California
$2,294
per week
Registered Nurse - Infusion
Irvine
$56.31
per hour
California
$59.67
per hour
Registered Nurse
Irvine
$51.82
per hour
California
$55.40
per hour
Registered Nurse II
Irvine
$78,273
per year
California
$166,705
per year
Licensed Vocational Nurse
Irvine
$33.61
per hour
California
$36.44
per hour
Job descriptions below are for educational purposes. Please refer to the employer's job description for complete details.
-
Nurse Practitioner
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Please refer to the employers job description for complete details.
Nurse Practitioners diagnose patients, prescribe medications, and collaborate with healthcare teams. Requires advanced clinical skills, autonomy in practice, and a valid NP license.
The top companies hiring Nurse Practitioner in Irvine, CA are City of Hope (5 jobs), Kaiser Permanente (1 job), and PSI (1 job).
Nurse Practitioner jobs take 99 days on average from job posting to starting date. Currently, 10% of job openings offer remote or hybrid positions and 22% of job openings are part-time roles.
See 102 jobsAverage pay
Irvine
$82.72 per hourCalifornia
$107 per hourSkills
- Nursing
- Primary care
- Patient care
- EMR systems
- Communication skills
-
Senior Clinical Nurse
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Please refer to the employers job description for complete details.
Senior clinical nurses plan patient care strategies, supervise nursing staff and manage complex cases. Advanced clinical expertise, excellent leadership skills and in-depth knowledge of patient care are essential in this role.
The top companies hiring Senior Clinical Nurse in Irvine, CA are City of Hope (4 jobs), UC Irvine Health (4 jobs), and Hoag Health System (1 job).
Currently, 30% of job openings are part-time roles.
See 28 jobsAverage pay
Irvine
$72.37 per hourCalifornia
$85.67 per hourSkills
- Medical-surgical
- ICU experience
- Surgery
- Time management
- English
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Nurse Manager
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Please refer to the employers job description for complete details.
Nurse Managers supervise nursing staff, develop care standards, and manage department budgets. Key skills include leadership expertise, clinical knowledge, and financial management.
The top companies hiring Nurse Manager in Irvine, CA are City of Hope (2 jobs), UC Irvine Health (1 job), and Mission Healthcare (1 job).
Nurse Manager jobs take 35 days on average from job posting to starting date. Currently, 3% of job openings are part-time roles.
See 21 jobsAverage pay
Irvine
$138,527 per yearCalifornia
$146,116 per yearSkills
- Nursing
- Management
- Supervising experience
- Patient care
- Leadership
-
Registered Nurse Case Manager
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Please refer to the employers job description for complete details.
RN Case Managers coordinate patient care plans, assess treatment options, and collaborate with healthcare teams. Expertise in case management, strong assessment skills, and communication abilities are essential.
The top companies hiring Registered Nurse Case Manager in Irvine, CA are Acacia Health (4 jobs), UC Irvine Health (1 job), and Newport Hospice (1 job).
Registered Nurse Case Manager jobs take 54 days on average from job posting to starting date. Currently, 11% of job openings are part-time roles.
See 29 jobsAverage pay
Irvine
$2,624 per weekCalifornia
$2,601 per weekSkills
- Case management
- Hospice care
- Home & community care experience
- Discharge planning
- Home health
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Registered Nurse - Home Health
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Please refer to the employers job description for complete details.
Registered Nurses - Home Health provide patient care, monitor health conditions, and liaise with healthcare teams. Nursing degree, licensure, and ability to work independently ensure quality patient support.
The top companies hiring Registered Nurse - Home Health in Irvine, CA are Providence at Home with Compassus (6 jobs), Acacia Health (5 jobs), and Alliance Health Services (2 jobs).
Registered Nurse - Home Health jobs take 67 days on average from job posting to starting date. Currently, 26% of job openings are part-time roles.
See 89 jobsAverage pay
Irvine
$2,601 per weekCalifornia
$2,294 per weekSkills
- Nursing
- Patient care
- Medication administration
- Home health
- Care plans
-
Registered Nurse - Infusion
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Please refer to the employers job description for complete details.
Registered infusion nurses administer IV medications, monitor patient responses and ensure quality care. A nursing license, proficiency in IV therapy and strong communication skills are essential.
The top companies hiring Registered Nurse - Infusion in Irvine, CA are Hydration Room (3 jobs), Medical Clinic (1 job), and Orbit Infusion Solutions, LLC (1 job).
Registered Nurse - Infusion jobs take 67 days on average from job posting to starting date. Currently, 42% of job openings are part-time roles.
See 43 jobsAverage pay
Irvine
$56.31 per hourCalifornia
$59.67 per hourSkills
- IV infusion
- IV insertion
- Oncology
- Home health
- Acute care
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Registered Nurse
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Please refer to the employers job description for complete details.
Registered Nurses provide patient care, administer treatments, and coordinate with healthcare teams. Nursing licensure, clinical expertise, and strong communication skills are essential.
The top companies hiring Registered Nurse in Irvine, CA are Kaiser Permanente (6 jobs), VITAS Healthcare (2 jobs), and Synergy Staffing LLC (1 job).
Registered Nurse jobs take 53 days on average from job posting to starting date. Currently, 23% of job openings are part-time roles.
See 206 jobsAverage pay
Irvine
$51.82 per hourCalifornia
$55.40 per hourSkills
- Nursing
- Patient care
- Physiology knowledge
- Medical documentation
- Hindi
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Registered Nurse II
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Please refer to the employers job description for complete details.
Registered nurses provide patient care, administer medications and collaborate with healthcare teams. Nursing expertise, strong communication skills and licensure as a registered nurse are required.
Registered Nurse II jobs take 14 days on average from job posting to starting date. Currently, 19% of job openings are part-time roles.
See 51 jobsAverage pay
Irvine
$78,273 per yearCalifornia
$166,705 per yearSkills
- Discharge planning
- Computer skills
- Leadership
- Acute care
- Medication administration
-
Licensed Vocational Nurse
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Please refer to the employers job description for complete details.
Licensed Vocational Nurses provide patient care, administer medications, and document treatments. Clinical knowledge, empathy, and attention to procedural details are critical for ensuring patient well-being.
The top companies hiring Licensed Vocational Nurse in Irvine, CA are UC Irvine Health (2 jobs), MemorialCare (1 job), and Hoag Health System (1 job).
Licensed Vocational Nurse jobs take 58 days on average from job posting to starting date. Currently, 27% of job openings are part-time roles.
See 257 jobsAverage pay
Irvine
$33.61 per hourCalifornia
$36.44 per hourSkills
- Nursing
- Medication administration
- Patient care
- Care plans
- Long term care experience