High-paying nursing jobs in Charleston
Nursing is caring for patients and managing healthcare. Nurses provide essential support by monitoring patient conditions and administering treatments. They need empathy, attention to detail, and strong communication skills to deliver quality care.
The 416 nursing jobs listed below pay well, with salaries between $40,684 and $166,425 per year. Registered Nurse, Nursing Assistant and Licensed Practical Nurse are among the most popular high-paying roles in Charleston, SC.
Job title
Updated Nov 07, 2026Nurse Practitioner
Charleston
South Carolina
Psychiatric-mental Health Nurse Practitioner
Charleston
South Carolina
Advanced Practice Provider
Charleston
South Carolina
Registered Nurse - Icu
Charleston
South Carolina
Registered Nurse - Operating Room
Charleston
South Carolina
Registered Nurse
Charleston
South Carolina
Registered Nurse - Emergency Room
Charleston
South Carolina
Registered Nurse - Medical/Surgical
Charleston
South Carolina
Licensed Practical Nurse
Charleston
South Carolina
Nursing Assistant
Charleston
South Carolina
Job descriptions below are for educational purposes. Please refer to the employer's job description for complete details.
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Nurse Practitioner
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Please refer to the employers job description for complete details.
Nurse Practitioners diagnose patients, prescribe medications, and collaborate with healthcare teams. Requires advanced clinical skills, autonomy in practice, and a valid NP license.
The top companies hiring Nurse Practitioner in Charleston, SC are Matrix Medical Network (3 jobs), Restore Hyper Wellness (2 jobs), and West Coast Wound & Skin Care (2 jobs).
Nurse Practitioner jobs take 101 days on average from job posting to starting date. Currently, 13% of job openings offer remote or hybrid positions and 20% of job openings are part-time roles.
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Charleston
$85.31 per hourSouth Carolina
$91.96 per hour -
Psychiatric-mental Health Nurse Practitioner
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Please refer to the employers job description for complete details.
Psychiatric-mental health nurse practitioners diagnose disorders, prescribe treatments and support patients. Advanced nursing expertise, empathetic communication and licensure are essential in this role.
The top companies hiring Psychiatric-mental Health Nurse Practitioner in Charleston, SC are CHE Behavioral Health Services (1 job), Ally Psychiatry (1 job), and Legion Health (1 job).
Psychiatric-mental Health Nurse Practitioner jobs take 91 days on average from job posting to starting date. Currently, 58% of job openings offer remote or hybrid positions and 23% of job openings are part-time roles.
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Charleston
$166,425 per yearSouth Carolina
$147,284 per year -
Advanced Practice Provider
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Advanced practice providers deliver advanced clinical care, conduct patient assessments and collaborate with physicians to develop treatment plans. They need clinical expertise, knowledge of healthcare protocols and strong communication skills.
The top companies hiring Advanced Practice Provider in Charleston, SC are TeamHealth (1 job), Trident Medical Center (1 job), and Oak Street Health, part of CVS Health (1 job).
Advanced Practice Provider jobs take 53 days on average from job posting to starting date. Currently, 13% of job openings are part-time roles.
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Charleston
$126,842 per yearSouth Carolina
$116,584 per year -
Registered Nurse - Icu
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Please refer to the employers job description for complete details.
ICU Registered Nurses monitor patient vitals, administer medication, and provide critical care support. Expertise in critical patient care, strong clinical judgment, and certifications are key.
The top companies hiring Registered Nurse - Icu in Charleston, SC are American Traveler (6 jobs), Trident Medical Center (4 jobs), and HealthTrust Workforce Solutions (2 jobs).
Registered Nurse - Icu jobs take 39 days on average from job posting to starting date. Currently, 11% of job openings are part-time roles.
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Charleston
$1,940 per weekSouth Carolina
$1,904 per weekSkills
- Nursing
- Patient care
- Physiology knowledge
- Medical documentation
- ICU experience
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Registered Nurse - Operating Room
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Registered Nurses in the Operating Room assist during surgeries, monitor patient status, and maintain sterile environments. Expertise in surgical procedures, attention to detail, and strong communication skills are essential.
The top companies hiring Registered Nurse - Operating Room in Charleston, SC are American Traveler (8 jobs), Vibra Travels (5 jobs), and Voyage Health (3 jobs).
Registered Nurse - Operating Room jobs take 112 days on average from job posting to starting date. Currently, 10% of job openings are part-time roles.
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Charleston
$1,909 per weekSouth Carolina
$1,969 per weekSkills
- Nursing
- Patient care
- Medical documentation
- Physiology knowledge
- Medical terminology
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Registered Nurse
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Registered Nurses provide patient care, administer treatments, and coordinate with healthcare teams. Nursing licensure, clinical expertise, and strong communication skills are essential.
The top companies hiring Registered Nurse in Charleston, SC are Roper St. Francis Healthcare (32 jobs), Trident Medical Center (7 jobs), and HealthTrust Workforce Solutions (4 jobs).
Registered Nurse jobs take 67 days on average from job posting to starting date. Currently, 24% of job openings are part-time roles.
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Charleston
$1,836 per weekSouth Carolina
$1,827 per weekSkills
- Nursing
- Patient care
- Physiology knowledge
- Medical documentation
- Hindi
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Registered Nurse - Emergency Room
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ER Registered Nurses provide critical care, assess patient needs, and collaborate with healthcare teams under pressure. Expertise in emergency care, quick decision-making, and excellent communication skills are crucial for success.
The top companies hiring Registered Nurse - Emergency Room in Charleston, SC are Roper St. Francis Healthcare (5 jobs), Novant Health (5 jobs), and Vibra Travels (4 jobs).
Registered Nurse - Emergency Room jobs take 51 days on average from job posting to starting date. Currently, 15% of job openings are part-time roles.
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Charleston
$1,726 per weekSouth Carolina
$1,836 per weekSkills
- Nursing
- Physiology knowledge
- Medical documentation
- Patient care
- Medical records
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Registered Nurse - Medical/Surgical
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Registered nurses in medical-surgical care provide patient care, monitor vitals and administer treatments. Expertise in nursing procedures, patient assessment, and emergency response is essential in this role.
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Charleston
$1,644 per weekSouth Carolina
$1,814 per week -
Licensed Practical Nurse
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Licensed Practical Nurses provide patient care, monitor vital signs, and assist doctors. Nursing license, proficiency in medical equipment, and strong interpersonal skills are essential.
The top companies hiring Licensed Practical Nurse in Charleston, SC are National HealthCare Corporation (4 jobs), Vistelan Healthcare LLC (4 jobs), and Optum (2 jobs).
Licensed Practical Nurse jobs take 58 days on average from job posting to starting date. Currently, 33% of job openings are part-time roles.
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Charleston
$30.49 per hourSouth Carolina
$31.25 per hour -
Nursing Assistant
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Nursing Assistants assist with patient care, monitor vital signs, and support nursing staff. Compassionate demeanor, basic knowledge of medical procedures, and physical stamina are essential attributes.
The top companies hiring Nursing Assistant in Charleston, SC are Vistelan Healthcare LLC (7 jobs), Heart'n Soul Hospice (3 jobs), and BAYADA Home Health Care (2 jobs).
Nursing Assistant jobs take 59 days on average from job posting to starting date. Currently, 42% of job openings are part-time roles.
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Charleston
$18.01 per hourSouth Carolina
$17.16 per hourSkills
- Nursing
- Patient care
- Medical documentation
- Physiology knowledge
- Medical records