High-paying nursing jobs in Columbia
Nursing is caring for patients and managing healthcare. Nurses provide essential support by monitoring patient conditions and administering treatments. They need empathy, attention to detail, and strong communication skills to deliver quality care.
The 512 nursing jobs listed below pay well, with salaries between $40,281 and $127,132 per year. Registered Nurse, Licensed Practical Nurse and Nursing Assistant are among the most popular high-paying roles in Columbia, SC.
Job title
Updated Nov 12, 2026Nurse Practitioner
Columbia
South Carolina
Registered Nurse - Acute Care
Columbia
South Carolina
Advanced Practice Provider
Columbia
South Carolina
Registered Nurse - Medical/Surgical
Columbia
South Carolina
Nursing Supervisor
Columbia
South Carolina
Registered Nurse
Columbia
South Carolina
Charge Nurse
Columbia
South Carolina
Licensed Practical Nurse
Columbia
South Carolina
Registered Nurse - Home Health
Columbia
South Carolina
Nursing Assistant
Columbia
South Carolina
Job descriptions below are for educational purposes. Please refer to the employer's job description for complete details.
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Nurse Practitioner
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Nurse Practitioners diagnose patients, prescribe medications, and collaborate with healthcare teams. Requires advanced clinical skills, autonomy in practice, and a valid NP license.
The top companies hiring Nurse Practitioner in Columbia, SC are Prisma Health (18 jobs), Lexington Health (4 jobs), and Matrix Medical Network (4 jobs).
Nurse Practitioner jobs take 97 days on average from job posting to starting date. Currently, 15% of job openings offer remote or hybrid positions and 20% of job openings are part-time roles.
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Columbia
$127,132 per yearSouth Carolina
$123,643 per year -
Registered Nurse - Acute Care
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Registered nurses in acute care monitor patient status, coordinate treatments and administer medications. Essential skills include acute care experience, clinical knowledge and patient-centered focus.
Registered Nurse - Acute Care jobs take 71 days on average from job posting to starting date. Currently, 18% of job openings are part-time roles.
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Columbia
$2,286 per weekSouth Carolina
$2,044 per week -
Advanced Practice Provider
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Advanced practice providers deliver advanced clinical care, conduct patient assessments and collaborate with physicians to develop treatment plans. They need clinical expertise, knowledge of healthcare protocols and strong communication skills.
The top companies hiring Advanced Practice Provider in Columbia, SC are Medical University of South Carolina (12 jobs), CVS Health (2 jobs), and Commonwealth Pain & Spine (2 jobs).
Advanced Practice Provider jobs take 51 days on average from job posting to starting date. Currently, 12% of job openings are part-time roles.
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Columbia
$55.77 per hourSouth Carolina
$58.26 per hour -
Registered Nurse - Medical/Surgical
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Registered nurses in medical-surgical care provide patient care, monitor vitals and administer treatments. Expertise in nursing procedures, patient assessment, and emergency response is essential in this role.
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Columbia
$1,876 per weekSouth Carolina
$1,813 per week -
Nursing Supervisor
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Nursing Supervisors oversee nursing staff, ensure patient care standards, and coordinate shifts. Leadership skills, clinical expertise, and proficiency in healthcare regulations are essential.
The top companies hiring Nursing Supervisor in Columbia, SC are BAYADA Home Health Care (4 jobs), RecSol Recovery Solutions (3 jobs), and National HealthCare Corporation (2 jobs).
Nursing Supervisor jobs take 56 days on average from job posting to starting date. Currently, 25% of job openings are part-time roles.
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Columbia
$91,163 per yearSouth Carolina
$87,734 per yearSkills
- Supervising experience
- Team management
- Nursing
- Medical terminology
- Medical records
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Registered Nurse
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Registered Nurses provide patient care, administer treatments, and coordinate with healthcare teams. Nursing licensure, clinical expertise, and strong communication skills are essential.
The top companies hiring Registered Nurse in Columbia, SC are Medical University of South Carolina (30 jobs), Prisma Health (22 jobs), and Fresenius Medical Care (7 jobs).
Registered Nurse jobs take 65 days on average from job posting to starting date. Currently, 24% of job openings are part-time roles.
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Columbia
$1,712 per weekSouth Carolina
$1,828 per weekSkills
- Nursing
- Patient care
- Physiology knowledge
- Medical documentation
- Hindi
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Charge Nurse
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Charge nurses lead nursing teams, coordinate patient care and manage staff schedules. Key qualifications include maintaining a registered nurse license, leadership skills and strong clinical expertise.
The top companies hiring Charge Nurse in Columbia, SC are Lutheran Homes of South Carolina (9 jobs), Armor Health (2 jobs), and Midlands Health and Rehabilitation Center (1 job).
Charge Nurse jobs take 78 days on average from job posting to starting date. Currently, 15% of job openings are part-time roles.
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Columbia
$38.18 per hourSouth Carolina
$31.87 per hourSkills
- Nursing
- Medical documentation
- Medical records
- Physiology knowledge
- Medical terminology
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Licensed Practical Nurse
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Licensed Practical Nurses provide patient care, monitor vital signs, and assist doctors. Nursing license, proficiency in medical equipment, and strong interpersonal skills are essential.
The top companies hiring Licensed Practical Nurse in Columbia, SC are Medical University of South Carolina (8 jobs), PruittHealth (5 jobs), and Prisma Health (4 jobs).
Licensed Practical Nurse jobs take 58 days on average from job posting to starting date. Currently, 33% of job openings are part-time roles.
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Columbia
$34.01 per hourSouth Carolina
$31.25 per hour -
Registered Nurse - Home Health
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Registered Nurses - Home Health provide patient care, monitor health conditions, and liaise with healthcare teams. Nursing degree, licensure, and ability to work independently ensure quality patient support.
The top companies hiring Registered Nurse - Home Health in Columbia, SC are CenterWell (6 jobs), PruittHealth (3 jobs), and Interim HealthCare (2 jobs).
Registered Nurse - Home Health jobs take 56 days on average from job posting to starting date. Currently, 27% of job openings are part-time roles.
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Columbia
$33.68 per hourSouth Carolina
$33.10 per hour -
Nursing Assistant
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Nursing Assistants assist with patient care, monitor vital signs, and support nursing staff. Compassionate demeanor, basic knowledge of medical procedures, and physical stamina are essential attributes.
The top companies hiring Nursing Assistant in Columbia, SC are Lutheran Homes of South Carolina (5 jobs), PruittHealth (5 jobs), and National HealthCare Corporation (3 jobs).
Nursing Assistant jobs take 59 days on average from job posting to starting date. Currently, 42% of job openings are part-time roles.
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Columbia
$17.83 per hourSouth Carolina
$17.16 per hourSkills
- Nursing
- Patient care
- Medical documentation
- Physiology knowledge
- Medical records